MVK and HIP1R

		MVK	HIP1R
Description		mevalonate kinase	huntingtin interacting protein 1 related
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GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol	Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Endomembrane System Postsynaptic Density Membrane Apical Plasma Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Perinuclear Region Of Cytoplasm Synaptic Membrane Postsynapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding	Actin Binding Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Sterol Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Negative Regulation Of Inflammatory Response	Endocytosis Receptor-mediated Endocytosis Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Digestive System Development Regulation Of Gastric Acid Secretion Membrane Organization Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Postsynapse Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs		Farnesyl thiopyrophosphate
Diseases		Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Aspartate aminotransferase levels ( 29403010) Cataracts ( 34127677) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 19060906 30275531 25961943 24097068 20864672 20686565 18193043) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414) Serum metabolite levels ( 33031748)	A body shape index ( 34021172) Atrial fibrillation ( 29892015 30061737) Body mass index ( 29273807) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: CEBPA EIF4E2 EWSR1 GLTP HIP1R POT1 PTPN11 RNF141 SELPLG TERF1	18 interacting genes: ACTA1 ACTB CIT CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT MVK NEK1 PRICKLE1 PTPN11 TFIP11 TRIM27 UBC
Entrez ID		4598	9026
HPRD ID		02015	10412
Ensembl ID		ENSG00000110921	ENSG00000130787
Uniprot IDs		B2RDU6 B7Z1C2 B7Z301 F5H8H2 Q03426	B3KQW8 B4DPL0 O75146
PDB IDs		2R3V	1R0D
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Inner Ear Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Clathrin Coat Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Intestinal Epithelial Cell Migration Leukocyte Adhesive Activation Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Biosynthetic Process Positive Regulation Of Telomeric Loop Disassembly DNA Biosynthetic Process Cytokine-mediated Signaling Pathway CHOP-C/EBP Complex Regulation Of Protein-containing Complex Assembly Cerebellar Cortex Formation Telomere Maintenance Positive Regulation Of Chromosome Organization Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Clathrin Coat Assembly 8-hydroxy-2'-deoxyguanosine DNA Binding	Cytosol Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Pit Clathrin Coat Of Coated Pit Clathrin Vesicle Coat Vesicle-mediated Transport Presynaptic Endocytic Zone Membrane Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytoplasm Endocytosis Clathrin-dependent Endocytosis Intracellular Transport Nitric-oxide Synthase Regulator Activity Receptor-mediated Endocytosis Import Into Cell Cytoplasmic Vesicle Membrane Clathrin Complex Clathrin Light Chain Binding Postsynaptic Actin Cytoskeleton Clathrin Heavy Chain Binding Profilin Binding Cytoskeleton Regulation Of Cellular Component Organization Clathrin-coated Vesicle Cellular Localization Establishment Of Localization In Cell Actin Filament Regulation Of Organelle Organization Neuron Projection Morphogenesis Structural Constituent Of Cytoskeleton Cell Projection Morphogenesis Endolysosome Membrane Intracellular Protein Transport Developmental Process Cortical Cytoskeleton Peptide Binding Plasma Membrane Bounded Cell Projection Assembly Face Morphogenesis Cell Projection Assembly Axonogenesis Protein Transport Dynein Intermediate Chain Binding Clathrin Binding Cell Projection Organization Lamellipodium Anatomical Structure Homeostasis Tissue Homeostasis Substantia Nigra Development
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