BORCS8-MEF2B and GDF15

		BORCS8-MEF2B	GDF15
Description		BORCS8-MEF2B readthrough	growth differentiation factor 15
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Cell Junction	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Heart Development Muscle Organ Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development	Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Leukocyte Migration Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Cellular Response To Chemical Stress Energy Homeostasis GDF15-GFRAL Signaling Pathway Response To Metformin Positive Regulation Of Myoblast Fusion
Pathways		Myogenesis
Drugs
Diseases
GWAS		Height ( 28552196) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		10 interacting genes: AGR2 CABIN1 CTAG1A CTAG1B GDF15 HDAC4 MESD TEAD1 TEKT4 TEX11	20 interacting genes: ALOX5AP BORCS8-MEF2B BRME1 CBX3 COPE EHF FCHO1 HOMER3 HOXA1 IL27RA KRTAP12-2 MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1 TACC3
Entrez ID		4207	9518
HPRD ID		02808	05608
Ensembl ID		ENSG00000213999	ENSG00000130513
Uniprot IDs		Q02080	Q99988
PDB IDs		1N6J 1TQE 6BYY 6BZ1 6C9L 6WC2 6WC5	5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?		TRNA Threonylcarbamoyladenosine Metabolic Process
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