ME1 and AP1B1

		ME1	AP1B1
Description		malic enzyme 1	adaptor related protein complex 1 subunit beta 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System Membrane Membrane Coat AP-1 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane
	Molecular Function	Magnesium Ion Binding Malic Enzyme Activity Malate Dehydrogenase (decarboxylating) (NADP+) Activity Protein Binding Oxaloacetate Decarboxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Manganese Ion Binding Identical Protein Binding ADP Binding Metal Ion Binding NADP Binding NAD Binding	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Carbohydrate Metabolic Process Pyruvate Metabolic Process Malate Metabolic Process NADP+ Metabolic Process Nucleotide Biosynthetic Process Response To Hormone Response To Carbohydrate NAD+ Metabolic Process Protein Homotetramerization Regulation Of NADP Metabolic Process	Kidney Development Intracellular Protein Transport Determination Of Left/right Symmetry Heart Development Protein Transport Vesicle-mediated Transport Platelet Dense Granule Organization Basolateral Protein Secretion Melanosome Assembly
Pathways		PPARA activates gene expression Pyruvate metabolism NFE2L2 regulating TCA cycle genes Regulation of pyruvate metabolism	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs		NADH Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Bipolar disorder ( 33169155) Birth weight ( 31043758) Serum polyunsaturated fatty acid concentration x Mediterranean diet adherence interaction in metabolic syndrome ( 31991592)	Aspartate aminotransferase levels ( 33547301) Carotid atherosclerosis in HIV infection ( 20009918) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Pancreatic cancer ( 25086665) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		3 interacting genes: AP1B1 MAPK1 OGT	53 interacting genes: - AGR3 AP1G1 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CDC42EP1 CEBPA CIMIP4 CLTC CREBBP CRYBB1 CYTH4 FARS2 FBXO7 FILNC1 FMNL2 FNDC11 GPANK1 GTF2I KIF13A LDLRAP1 ME1 MLH1 MSGN1 MTNR1B MYG1 NECAP1 NTRK2 NUP54 PARD3 PHF5A PIP5K1C PLK2 POM121 PRKDC PSME1 PSORS1C2 RNF39 SHBG SLC2A8 SMAD2 TBC1D22B TSGA10IP U2AF1
Entrez ID		4199	162
HPRD ID		01102	02541
Ensembl ID		ENSG00000065833	ENSG00000100280
Uniprot IDs		P48163	Q10567
PDB IDs		2AW5 3WJA 7X11 7X12	4HMY 4P6Z 6CM9 6CRI 6D83 6D84 6DFF 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9T 8D9U 8D9V 8D9W
Enriched GO Terms of Interacting Partners?		Heart Development Basolateral Protein Secretion Early Endosome Regulation Of Lipid Metabolic Process Cardiac Neural Crest Cell Development Involved In Heart Development Caveolin-mediated Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Golgi Inheritance Cytosine Metabolic Process Interleukin-34-mediated Signaling Pathway Cellular Response To Nutrient Levels Positive Regulation Of Macrophage Proliferation Trachea Formation Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Transcription By Glucose Positive Regulation Of Peptidyl-threonine Phosphorylation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Bergmann Glial Cell Differentiation NSL Complex Clathrin Adaptor Complex AP-1 Adaptor Complex Platelet Dense Granule Organization Melanosome Assembly Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Localization Response To Nutrient Levels Face Development Positive Regulation Of Neuroinflammatory Response Labyrinthine Layer Blood Vessel Development Regulation Of Golgi Organization Regulation Of Protein Modification Process Peptidyl-threonine Phosphorylation MAP Kinase Activity Pyrimidine Nucleobase Metabolic Process Cellular Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Schwann Cell Development	Histone H2AXS139 Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Presynaptic Endocytosis Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of Cell Cycle Regulation Of Cellular Response To Heat Intracellular Protein Localization Regulation Of Cell Cycle Clathrin Adaptor Activity Negative Regulation Of Cell Cycle Process Establishment Of Protein Localization DNA-dependent Protein Kinase Activity Intracellular Protein Transport Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Cell Cycle Phase Transition Clathrin-coated Pit Protein Transport Basolateral Protein Secretion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Cell Cycle Clathrin-coated Vesicle Membrane Vesicle-mediated Transport In Synapse MutSalpha Complex Binding Homologous Recombination Synaptic Vesicle Endocytosis Negative Regulation Of Mitotic Nuclear Division Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Telomere Localization Protein Localization To Chromosome Somatic Cell DNA Recombination Trans-Golgi Network Membrane Endocytosis Somitogenesis Meiotic Sister Chromatid Cohesion Male Meiotic Nuclear Division Nucleotide Binding Regulation Of Receptor-mediated Endocytosis Segmentation Response To Gamma Radiation Mitotic G2/M Transition Checkpoint
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