MATK and NFIX

		MATK	NFIX
Description		megakaryocyte-associated tyrosine kinase	nuclear factor I X
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Chromatin Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Downregulation of ERBB2 signaling	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661)	Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area ( 32963231) Cortical volume ( 32963231) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		26 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 GPX4 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NFIX NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC	32 interacting genes: ARL4A GADD45B GZMA JMJD6 LHX4 MATK MLLT1 NFIB NRTN PAX2 PAX6 PAX7 PAX8 PIR POLR2E PRDM1 QRICH1 RFX1 RWDD1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614
Entrez ID		4145	4784
HPRD ID		02496	01234
Ensembl ID		ENSG00000007264	ENSG00000008441
Uniprot IDs		F1T0G6 P42679	B4DHW2 D2DXM9 Q14938
PDB IDs		1JWO 1X6G 3US4	7QQD 7QQE
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Kinase Activity Positive Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation ATP Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Protein Phosphorylation ERBB Signaling Pathway Nucleotide Binding Phosphorylation Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Signal Transduction Receptor Complex Positive Regulation Of Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Apoptotic Process Cell Differentiation Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Regulation Of Developmental Process Positive Regulation Of Cellular Component Biogenesis Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Modification Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Signal Complex Assembly Signaling Receptor Activator Activity Regulation Of Protein Modification Process Regulation Of Anatomical Structure Morphogenesis	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization
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