TM4SF1 and ATP1B1

		TM4SF1	ATP1B1
Description		transmembrane 4 L six family member 1	ATPase Na+/K+ transporting subunit beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Binding	ATPase Activator Activity P-type Sodium:potassium-exchanging Transporter Activity Protein Binding Protein Kinase Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding Transporter Activator Activity
	Biological Process	Blastocyst Formation	Response To Hypoxia Immune System Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Metal Ion Transport Intracellular Potassium Ion Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft Innate Immune Response ATP Metabolic Process Protein Stabilization Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways			Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Bisacodyl Tegoprazan
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)	Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Electrocardiographic traits (multivariate) ( 32602732) Fuchs's corneal dystrophy ( 28358029) Haemorrhoidal disease ( 33888516) Keratoconus ( 33649486) Mitochondrial DNA levels ( 25240745) QT interval ( 19305409 23166209 24952745 29213071 29874175) Rosacea symptom severity ( 29771307)
Interacting Genes		9 interacting genes: ANPEP ATP1B1 BRD4 DDR1 DNAJA1 HSPA8 SDCBP2 SLC13A1 TUBA4A	30 interacting genes: AGTR1 BACE1 BARD1 BRCA1 CD84 CREG1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HCRTR1 HTR2B KMT2B LRIF1 NDRG2 OGT PAXIP1 PRRX1 PSME1 SERPINC1 THOC1 TM4SF1 TMEM132D TRIM14 TRMT2A TSC22D2 USP4
Entrez ID		4071	481
HPRD ID		01854	01663
Ensembl ID		ENSG00000169908	ENSG00000143153
Uniprot IDs		F8WF27 P30408	A3KLL5 P05026
PDB IDs			7E1Z 7E20 7E21 8D3U 8D3V 8D3W 8D3X 8D3Y 8ZYJ
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Extracellular Exosome ATPase Activator Activity MHC Class II Protein Complex Binding Protein Refolding Protein-macromolecule Adaptor Activity Alanyl Aminopeptidase Activity Protein Transport Into Plasma Membrane Raft Smooth Muscle Cell-matrix Adhesion Protein Tyrosine Kinase Collagen Receptor Activity Response To Unfolded Protein G Protein-coupled Receptor Binding Heat Shock Protein Binding Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Enzyme Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Lumenal Side Of Lysosomal Membrane Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K8ac Reader Activity Histone H4K12ac Reader Activity Protein-folding Chaperone Binding Unfolded Protein Binding Regulation Of Protein Import Negative Regulation Of DNA Damage Checkpoint Histone H3K27ac Reader Activity Sodium Ion Transmembrane Transport Protein Transport Into Membrane Raft Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy P-TEFb Complex Binding Histone H4 Reader Activity Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Clathrin Coat Disassembly Histone H4K16ac Reader Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane P-type Sodium:potassium-exchanging Transporter Activity ATP Metabolic Process Sodium Ion Transport Regulation Of Potassium Ion Import Negative Regulation Of JUN Kinase Activity Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Chaperone-mediated Autophagy Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Secondary Active Sulfate Transmembrane Transporter Activity RNA Polymerase II C-terminal Domain Binding	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Chromatin Organization Angiotensin Type I Receptor Activity Protein K6-linked Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Metabolic Process Regulation Of DNA Damage Checkpoint Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Protein Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Modification Process Multivesicular Body, Internal Vesicle Lumen Hepatocyte Homeostasis Cardiac Muscle Hypertrophy Muscle Hypertrophy GTP Cyclohydrolase I Activity Negative Regulation Of Protein Glutathionylation Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport Adenosine Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Histone Methyltransferase Complex Nuclear Matrix Golgi-associated Vesicle Lumen C-methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process
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