RHOH and TMEM33

		RHOH	TMEM33
Description		ras homolog family member H	transmembrane protein 33
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Plasma Membrane Membrane	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Melanosome
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding Kinase Inhibitor Activity Protein Kinase Binding Small GTPase Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction T Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Mast Cell Activation Positive Regulation Of T Cell Differentiation	Immune System Process Response To Endoplasmic Reticulum Stress Innate Immune Response Membrane Organization Endoplasmic Reticulum Tubular Network Organization Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways		RHOH GTPase cycle
Drugs
Diseases
GWAS		Graves' disease ( 21841780) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pre-treatment viral load in HIV-1 infection ( 31219150)	Helping behaviour (self reported) ( 29324852) Neurociticism ( 29500382)
Interacting Genes		24 interacting genes: ARHGDIA ARHGDIB ARHGDIG BANP CCNH FAM90A1 GDI1 IQUB ITGB1BP1 KANK2 KCNH2 LRIF1 MBLAC1 MTX2 PLEKHA7 RIPPLY1 SCNM1 SORL1 SUOX TCF19 TGFBR1 TMEM33 UTP14A XPNPEP1	11 interacting genes: CCR9 DCAF4L1 GUF1 MTNR1A OR5F1 RHOH RPL9 RPS14 SIX6 SLC29A2 YIPF7
Entrez ID		399	55161
HPRD ID		03616	07680
Ensembl ID		ENSG00000168421	ENSG00000109133
Uniprot IDs		Q15669 Q6ICP4	P57088
PDB IDs
Enriched GO Terms of Interacting Partners?		Rho GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Targeting To Membrane Rho Protein Signal Transduction	Cytidine Transmembrane Transporter Activity Uracil Transmembrane Transport Thymine Transport Uridine Transmembrane Transport Inosine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Cytidine Transport Uracil Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transport Guanine Transmembrane Transporter Activity Pyrimidine Nucleoside Transport Guanine Transport Guanine Transmembrane Transport Adenosine Transport Hypoxanthine Transport Nucleoside Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity G Protein-coupled Receptor Activity Melatonin Receptor Activity Cytoplasmic Translation Translation Cytosolic Ribosome CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Nucleoside Transmembrane Transport Adenine Transport Nucleoside Transport Pyrimidine Nucleobase Transport Structural Constituent Of Ribosome Mitochondrial Ribosome Binding Kinase Inhibitor Activity T Cell Differentiation Purine Nucleobase Transmembrane Transport Vesicle Fusion With Golgi Apparatus Mast Cell Activation Membrane Purine Nucleobase Transport Ribosome
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