KDR and SHOX2

		KDR	SHOX2
Description		kinase insert domain receptor	SHOX homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Receptor Complex Membrane Raft Anchoring Junction Cell Periphery Sorting Endosome	Chromatin Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Integrin Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Growth Factor Binding Vascular Endothelial Growth Factor Binding Identical Protein Binding Cadherin Binding Hsp90 Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Maturation Endocardium Development Endothelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Mesenchymal Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Cell Migration Peptidyl-tyrosine Phosphorylation Hemopoiesis Cell Differentiation Lung Development Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Embryonic Hemopoiesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Post-embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Calcium Ion Homeostasis Epithelial Tube Morphogenesis Blood Vessel Endothelial Cell Differentiation Vascular Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Stem Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Bone Development Cellular Response To Hydrogen Sulfide Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Vasculogenesis	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Regulation Of Heart Rate Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Chondrocyte Development Sinoatrial Node Development Heart Valve Development Sinoatrial Valve Development Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Nervous System Development Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Embryonic Digestive Tract Morphogenesis Embryonic Morphogenesis Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Axonogenesis Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Muscle Tissue Morphogenesis Cardiac Pacemaker Cell Differentiation Sinoatrial Node Cell Development Stem Cell Proliferation Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Stem Cell Proliferation
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization Integrin cell surface interactions VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Sorafenib Sunitinib 1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Cediranib Vatalanib XL999 TG-100801 XL820 CYC116 Ramucirumab Pegdinetanib RAF-265 Linifanib IMC-1C11 Semaxanib Pazopanib Midostaurin Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib Lenvatinib Nintedanib Tivozanib Fostamatinib Erdafitinib Foretinib Ripretinib Pralsetinib Olinvacimab
Diseases
GWAS		Blood protein levels ( 30072576) Endometriosis ( 28537267) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FVC) ( 30804560) Mosquito bite size ( 28199695) Peak expiratory flow ( 30804560) Serum VEGFR2 concentration ( 25411163) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Body mass index ( 26426971) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 23563607 25429064 31562340) Idiopathic dilated cardiomyopathy ( 29495422) Lung cancer in never smokers ( 28604730) Monobrow ( 27182965) Neurociticism ( 29500382) Neuroticism ( 29255261) Pulse pressure ( 30224653)
Interacting Genes		71 interacting genes: ACP1 AIMP2 ALB ANXA5 ATR BMX BTRC CACNA1S CAV1 CBL CCDC88A CDH5 CHIC2 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 DUSP19 FBXO25 FBXW11 FLT1 FLT4 FRS2 FYN GABARAP GNA11 GNAQ GRB10 GRB2 GSTA2 HSP90AA1 ILKAP IQGAP1 ITGB3 KIT KPNA4 MAPK1 NCK1 NRP1 P2RY2 PDCL3 PLCG1 PLCG2 PPM1A PPM1B PTPN11 PTPN12 PTPN6 PTPRR RASA1 SERPINF1 SH2D2A SHB SHC1 SHC2 SHOX2 SNCA SRC SRP72 STAT1 STYX SYNGAP1 TIMP3 USP7 UTP3 VEGFA VEGFC VEGFD YES1	5 interacting genes: CBR3 CDK4 KDR TRIM29 ZDHHC17
Entrez ID		3791	6474
HPRD ID		01867	03936
Ensembl ID		ENSG00000128052	ENSG00000168779
Uniprot IDs		P35968	O60902
PDB IDs		1VR2 1Y6A 1Y6B 1YWN 2M59 2MET 2MEU 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 3WZD 3WZE 4AG8 4AGC 4AGD 4ASD 4ASE 5EW3 5OYJ 6GQO 6GQP 6GQQ 6XVJ 6XVK
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Cytoplasm Regulation Of Vasculature Development Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor 2 Binding Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Programmed Cell Death Response To Platelet-derived Growth Factor T Cell Costimulation Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Population Proliferation Cell Motility SH3 Domain Binding Developmental Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Cytosol Ephrin Receptor Signaling Pathway Focal Adhesion Immune Response-activating Signaling Pathway Protein Dephosphorylation	Phylloquinone Catabolic Process 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity NADPH Dehydrogenase (quinone) Activity Vitamin K Catabolic Process Cyclin D2-CDK4 Complex Cyclin D1-CDK4 Complex Cellular Response To Ionomycin Cyclin D3-CDK4 Complex Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Response To Hydrogen Sulfide Cellular Response To Hydrogen Sulfide Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Positive Regulation Of Nitric Oxide Mediated Signal Transduction Sorting Endosome Post-embryonic Camera-type Eye Morphogenesis Endocardium Development Vascular Endothelial Growth Factor Binding Post-embryonic Eye Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carbonyl Reductase (NADPH) Activity Vitamin K Metabolic Process Cellular Response To Ether Regulation Of Type B Pancreatic Cell Proliferation Response To Phorbol 13-acetate 12-myristate Cellular Response To Phorbol 13-acetate 12-myristate Lymph Vessel Development Positive Regulation Of Membrane Depolarization Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Nitric Oxide Mediated Signal Transduction Endothelium Development Vascular Wound Healing Positive Regulation Of Vasculogenesis Positive Regulation Of Mitochondrial Depolarization Regulation Of CGMP-mediated Signaling Regulation Of Bone Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Golgi-associated Vesicle Membrane Ketone Catabolic Process NADPH Binding Regulation Of Epithelial Cell Proliferation
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