IL10 and TNFSF4

		IL10	TNFSF4
Description		interleukin 10	TNF superfamily member 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Activity Interleukin-10 Receptor Binding Protein Binding Growth Factor Activity Protein Dimerization Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Response To Molecule Of Bacterial Origin Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Immune Response Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of Gene Expression Negative Regulation Of Autophagy Response To Activity Response To Inactivity Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Response To Lipopolysaccharide Negative Regulation Of Interferon-alpha Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Response To Carbon Monoxide Cellular Response To Hepatocyte Growth Factor Stimulus Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Negative Regulation Of Cytokine Activity Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Endothelial Cell Apoptotic Process Liver Regeneration Interleukin-10-mediated Signaling Pathway Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of MiRNA Transcription Regulation Of Response To Wounding Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis Signaling by ALK fusions and activated point mutants	TNFs bind their physiological receptors
Drugs		CRx-139 LLL-3348
Diseases		Graft-versus-host disease Allograft rejection
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Behcet's disease ( 33393726 20622878 20622879) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 28008999 23128233) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Pediatric autoimmune diseases ( 26301688) Systemic lupus erythematosus ( 26502338 28714469 19838195) Type 1 diabetes ( 25751624 21829393 30572963 19430480) Ulcerative colitis ( 26398853 18836448 21297633 20228799 28067908 20228798 19915572)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 32296059 31361310 27182965 30929738 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 28714469 19838193 27399966 26663301 26502338 23273568 32771030 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)
Interacting Genes		14 interacting genes: A2M GLRX3 IL10RA IL10RB KRTAP1-3 KRTAP10-8 KRTAP4-1 NBPF19 NOTCH2NLA PTPRC S100A6 S100P TNFSF4 YY1	10 interacting genes: CERS2 COLGALT2 IL10 LTB4R PACSIN3 SMG7 SOAT1 TNFRSF4 TPR TRAF2
Entrez ID		3586	7292
HPRD ID		00495	04668
Ensembl ID		ENSG00000136634	ENSG00000117586
Uniprot IDs		A0A286YEX3 P22301 Q6FGW4	A0A024R937 P23510
PDB IDs		1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK 6X93 8SVE	2HEV
Enriched GO Terms of Interacting Partners?		Interleukin-10 Receptor Activity Calcium-dependent Protein Binding Interleukin-10-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Keratin Filament Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching Intermediate Filament Regulation Of Humoral Immune Response Negative Regulation Of Immune Response Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via STAT Interleukin-10 Binding Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Plasma Membrane Raft Distribution Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Immunoglobulin Production Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Defense Response Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Adaptive Immune Response Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of DNA Metabolic Process Positive Regulation Of T Cell Mediated Immunity Memory T Cell Activation Positive Regulation Of T Cell Costimulation Immunoglobulin Heavy Chain V-D-J Recombination Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of DNA Recombination Regulation Of Immunoglobulin Production Interleukin-8 Binding Interleukin-28 Receptor Complex Membrane Microdomain Negative Regulation Of Cytokine Production Positive Regulation Of B Cell Activation Defense Response To Nematode Response To Prostaglandin F Response To Lipid Alpha-beta T Cell Activation DN2 Thymocyte Differentiation Regulation Of T Cell Mediated Immunity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of T-helper 1 Cell Differentiation	Regulation Of Immunoglobulin Production Regulation Of Membrane Protein Ectodomain Proteolysis Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Positive Regulation Of Immune Effector Process Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Chronic Inflammatory Response Regulation Of B Cell Proliferation Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Receptor Binding Regulation Of Protein Metabolic Process Interleukin-10 Receptor Binding Mononuclear Cell Proliferation Lymphocyte Activation Negative Regulation Of Interleukin-18 Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Lymphocyte Proliferation Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Activity Positive Regulation Of B Cell Activation Regulation Of Cytokine Activity Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Cholesterol Storage Sterol O-acyltransferase Activity Cholesterol O-acyltransferase Activity RNA Export From Nucleus Nuclear Export Positive Regulation Of Chromatin Organization Negative Regulation Of RNA Export From Nucleus Positive Regulation Of Heterochromatin Formation MRNA Export From Nucleus MRNA Transport MRNA Export From Nucleus In Response To Heat Stress Nuclear Matrix Organization RNA Import Into Nucleus Sphingolipid Binding TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex IRE1-TRAF2-ASK1 Complex TORC1 Complex Assembly CD40 Receptor Binding
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