IL6R and MCL1

		IL6R	MCL1
Description		interleukin 6 receptor	MCL1 apoptosis regulator, BCL2 family member
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Bcl-2 Family Protein Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding	Protein Binding Protein Transmembrane Transporter Activity Channel Activity Protein Heterodimerization Activity BH Domain Binding BH3 Domain Binding
	Biological Process	Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Developmental Process Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Response To Cytokine Interleukin-11-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation T-helper 17 Cell Lineage Commitment Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation	Cell Fate Determination Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Autophagy Cellular Homeostasis Cell Differentiation Response To Cytokine Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Transmembrane Transport Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis Potential therapeutics for SARS	Interleukin-4 and Interleukin-13 signaling Signaling by ALK fusions and activated point mutants
Drugs		Tocilizumab Sarilumab Satralizumab
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187) Asthma ( 32296059 21907864) Atopic dermatitis ( 26482879) Atrial fibrillation ( 29892015) Blood protein levels ( 30072576 23696881) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein ( 19567438 18439548) C-reactive protein levels ( 30388399 29878111 29403010 21300955 33339817) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 26343387 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Interleukin-6 levels ( 33517400 32473944) Interleukin-6 levels in HIV infection ( 33095540) Iron status biomarkers (iron levels) ( 33536631) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387 33532862) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Platelet count ( 32888494) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307) Red cell distribution width ( 32888494) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 24390342 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34127860)	Blood protein levels ( 30072576) Coffee consumption ( 31959922) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) FEV1 ( 30804560) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Mean corpuscular hemoglobin ( 32888494) Melanoma ( 21983785) Monocyte count ( 29403010) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		15 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST IVL MAGI1 MCL1 PEX1 SGTB SLC39A2 SRC STAT3 WWP1 WWP2	42 interacting genes: APEX1 BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK BTRC CASP3 CDC20 CHRM4 DAD1 FBXW11 GSK3A GSK3B HIF1A HRK HUWE1 IL6R KCNF1 MAPK1 MAPK10 PCNA PDCD1 PIN1 PMAIP1 SIRT1 SIRT2 SIRT3 STX8 TNKS TPT1 TRAF6 TRIM11 UBXN6 UHRF2 USP9X VDAC1
Entrez ID		3570	4170
HPRD ID		01000	08870
Ensembl ID		ENSG00000160712	ENSG00000143384
Uniprot IDs		A0A087WTB5 A0N0L5 P08887	A0A087WT64 C8YZ26 Q07820
PDB IDs		1N26 1P9M 2ARW 5FUC 7DC8 8D82 8IOW 8QY5 8QY6	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8 6FS0 6FS1 6FS2 6MBD 6MBE 6NE5 6O4U 6O6F 6O6G 6OQB 6OQC 6OQD 6OQN 6OVC 6P3P 6QB3 6QB4 6QB6 6QFC 6QFI 6QFM 6QFQ 6QGD 6QXJ 6QYK 6QYL 6QYN 6QYO 6QYP 6QZ5 6QZ6 6QZ7 6QZ8 6QZB 6STJ 6U63 6U64 6U65 6U67 6U6F 6UA3 6UAB 6UD2 6UDI 6UDT 6UDU 6UDV 6UDX 6UDY 6VBX 6YBG 6YBJ 6YBK 6YBL 6ZIE 7NB4 7NB7 7XGE 8AV9 8EKX 8EL0 8EL1 8G3S 8G3T 8G3U 8G3W 8G3X 8G3Y 8H7B 8IQM 8QSO 8SVY 8T6F 8VJP 8Y1Y 8Y1Z 8Y20 9BCG 9CKN
Enriched GO Terms of Interacting Partners?		Interleukin-6 Receptor Binding Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via JAK-STAT T-helper Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Notch Signaling Pathway Negative Regulation Of Primary MiRNA Processing T Cell Lineage Commitment Positive Regulation Of Vascular Endothelial Growth Factor Production Interleukin-6 Receptor Complex Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Notch Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Production Ciliary Neurotrophic Factor Receptor Binding Interleukin-11-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of MiRNA Processing Cellular Developmental Process Retinal Rod Cell Differentiation Positive Regulation Of Extracellular Matrix Disassembly Intestinal Epithelial Cell Development Inflammatory Response To Wounding Positive Regulation Of Platelet Aggregation Positive Regulation Of Developmental Process Regulation Of MiRNA Processing Developmental Process Camera-type Eye Photoreceptor Cell Differentiation Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of Regulatory NcRNA Processing Protein Tyrosine Kinase Activator Activity Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Eye Photoreceptor Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Anoikis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Photoreceptor Cell Differentiation Symbiont Entry Into Host Cell Positive Regulation Of Cell-cell Adhesion Regulation Of Extracellular Matrix Disassembly Bone Resorption	Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Programmed Cell Death Regulation Of Organelle Organization Cellular Response To Stress Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Positive Regulation Of Membrane Permeability DNA Damage Response Mitochondrial Outer Membrane Regulation Of Autophagy Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cellular Response To Stress Regulation Of Neuron Apoptotic Process Mitochondrion Leukocyte Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Response To Stress Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Signal Transduction Organelle Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cellular Component Organization
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