HSPA6 and FCGR2B

		HSPA6	FCGR2B
Description		heat shock protein family A (Hsp70) member 6	Fc gamma receptor IIb
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Plasma Membrane External Side Of Plasma Membrane Membrane Dendritic Spine Cell Body
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Amyloid-beta Binding Protein Binding IgG Receptor Activity Low-affinity IgG Receptor Activity IgG Binding Protein-containing Complex Binding
	Biological Process	Protein Folding Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation	Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Cytokine Production Immune Effector Process Follicular Dendritic Cell Activation Mature B Cell Differentiation Involved In Immune Response Follicular B Cell Differentiation Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Immunoglobulin Production Regulation Of Immune System Process Regulation Of Adaptive Immune Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Receptor-mediated Endocytosis Phagocytosis Phagocytosis, Engulfment Defense Response Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellum Development Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-10 Production Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Negative Regulation Of Macrophage Activation Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Innate Immune Response Mast Cell Activation Positive Regulation Of JNK Cascade Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Negative Regulation Of Immune Response Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Neutrophil Activation Regulation Of Dendritic Spine Maintenance Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Dendritic Cell Differentiation
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Etanercept Human immunoglobulin G Abciximab Tositumomab Alemtuzumab Antithymocyte immunoglobulin (rabbit) Palivizumab Daclizumab Bevacizumab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233 28067908) Offspring birth weight ( 31043758) Ulcerative colitis ( 21297633 28067908)	Alanine aminotransferase levels ( 34315874) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 27680694 31043758) Blood protein levels ( 30072576) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) IgG levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Lipid metabolism phenotypes ( 22286219) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Rheumatoid arthritis ( 30423114) Serum total protein levels ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 21297633 28067908) White blood cell count ( 32888494 27863252)
Interacting Genes		20 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FCGR2B FLNA KRT222 LGALS7 LGALS7B MPZ PPIB PRAP1 RPA1 SNCA TERF1 WEE2-AS1	22 interacting genes: AP3B1 APCS BLK CRP ERG28 FCER1G FCGR2A GAB1 GRB2 HSPA6 INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 MGST3 MRTFB PRKCA PTPN11 PTPN6 ZBTB18
Entrez ID		3310	2213
HPRD ID		00775	06849
Ensembl ID		ENSG00000173110	ENSG00000072694
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	P31994
PDB IDs		3FE1	2FCB 3WJJ 5OCC
Enriched GO Terms of Interacting Partners?		Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Exocytosis Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Protein Stability Positive Regulation Of Organelle Organization Protein Sequestering Activity Intracellular Membrane-bounded Organelle Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of MRNA Modification Positive Regulation Of Triglyceride Transport Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cellular Component Organization	Regulation Of Immune System Process Regulation Of Immune Response Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune System Process B Cell Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Effector Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Defense Response Antigen Receptor-mediated Signaling Pathway Activation Of Immune Response Regulation Of Leukocyte Proliferation ERBB Signaling Pathway Regulation Of Cell Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process Bergmann Glial Cell Differentiation SH3 Domain Binding T Cell Costimulation Lymphocyte Mediated Immunity Response To Stress Neutrophil Activation Involved In Immune Response Peptidyl-tyrosine Phosphorylation Innate Immune Response Positive Regulation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Mediated Immunity Cell Surface Receptor Signaling Pathway Glial Cell Development Response To External Biotic Stimulus Schwann Cell Development Positive Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Defense Response To Symbiont Negative Regulation Of Lymphocyte Activation Defense Response Leukocyte Mediated Cytotoxicity Regulation Of Lymphocyte Activation Defense Response To Other Organism Insulin Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Protein Phosphorylation Intracellular Signal Transduction Regulation Of Lymphocyte Mediated Immunity
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