SETD2 and TEX264

		SETD2	TEX264
Description		SET domain containing 2, histone lysine methyltransferase	testis expressed 264, ER-phagy receptor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm	Autophagosome Membrane Extracellular Region Nucleus Replication Fork Chromosome Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Platelet Alpha Granule Lumen Cytoplasmic Vesicle
	Molecular Function	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Trimethyltransferase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Autophagosome Assembly Immune System Process DNA Repair Mismatch Repair Chromatin Organization Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II DNA Damage Response Response To Metal Ion Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Peptidyl-lysine Trimethylation Cell Differentiation Methylation Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Endodermal Cell Differentiation Response To Alkaloid Innate Immune Response Positive Regulation Of Ossification Stem Cell Differentiation Defense Response To Virus Protein K48-linked Ubiquitination Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin	DNA Repair Autophagy DNA Damage Response Reticulophagy Protein-DNA Covalent Cross-linking Repair
Pathways		PKMTs methylate histone lysines	Platelet degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Basophil count ( 32888494) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899) Huntington's disease progression ( 28642124) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 27863252 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		16 interacting genes: ARX ATXN1 CIC EXOSC7 GMPPB H3-4 H3C1 HTT KLHL18 NDUFAF3 SHANK3 SIAH2 SMAD3 SPOP TEX264 TMA7	29 interacting genes: ADGRG3 ARL13B CERS4 CLDN2 CLN6 COQ9 CREB3L1 EMP1 FAM209A FFAR2 FFAR3 GABARAPL2 GJB1 GPR152 GPR42 LHFPL4 LHFPL5 MFF MS4A3 NKX3-1 OPRM1 SETD2 SLC10A2 SLC34A2 SMIM3 TM4SF18 TMEM31 TMEM79 TSPAN12
Entrez ID		29072	51368
HPRD ID		11043	15492
Ensembl ID		ENSG00000181555	ENSG00000164081
Uniprot IDs		A0A1W2PPX9 Q9BYW2	A0A087WTU3 Q9Y6I9
PDB IDs		2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB 7EA8 7EVR 7EVS 7LZB 7LZD 7LZF 7TY2 7TY3 8Q5P 8RZU 9EGZ 9EH0 9EH1 9EH2	7VEC 7VED
Enriched GO Terms of Interacting Partners?		Vocal Learning Learning Social Behavior Observational Learning Auditory Behavior Learning Or Memory Mechanosensory Behavior Cognition Memory Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Chromatin Binding Proteasomal Protein Catabolic Process Lung Alveolus Development	Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Mucosal Immune Response Organ Or Tissue Specific Immune Response G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway GABA Receptor Binding
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