ARHGEF16 and TNFRSF18

		ARHGEF16	TNFRSF18
Description		Rho guanine nucleotide exchange factor 16	TNF receptor superfamily member 18
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding	Tumor Necrosis Factor Receptor Activity Protein Binding
	Biological Process	Regulation Of Cdc42 Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOG GTPase cycle	TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Response to statin therapy ( 20339536)	Inflammatory bowel disease ( 23128233)
Interacting Genes		12 interacting genes: AKT1 CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TAX1BP3 TFG TNFRSF18 YWHAQ	13 interacting genes: AKR1C1 ARHGEF16 BTK DZIP3 KCNAB2 LGALS8 LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2 WRAP73
Entrez ID		27237	8784
HPRD ID		12478	04879
Ensembl ID		ENSG00000130762	ENSG00000186891
Uniprot IDs		B3KTS4 Q5VV41	A0A0R7FDM1 Q9Y5U5
PDB IDs		1X6B	7KHD 7LAW
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Release Of Cytochrome C From Mitochondria Identical Protein Binding Regulation Of Protein Localization To Nucleus 14-3-3 Protein Binding Protein Localization To Nucleus Regulation Of Protein Localization To Cell Surface Negative Regulation Of Protein Localization Regulation Of Release Of Cytochrome C From Mitochondria Postsynapse Regulation Of TRNA Methylation Microtubule Plus End Polymerase	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Ubiquitin-protein Transferase Activity Alcohol Dehydrogenase (NADP+) Activity Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Ubiquitin Protein Ligase Activity Cytoplasm Cytokine-mediated Signaling Pathway Lymphocyte Activation Polyubiquitin Modification-dependent Protein Binding Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immune System Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Toll-like Receptor Signaling Pathway Leukocyte Activation Regulation Of Adaptive Immune Response Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity TORC2 Complex Disassembly Pinceau Fiber MWP Complex Positive Regulation Of Type I Hypersensitivity Cell Activation B Cell Affinity Maturation 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Ubiquitin Protein Ligase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Methylglyoxal Reductase (NADPH) (acetol Producing) Activity Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Immunoglobulin Production Zinc Ion Binding PDZ Domain Binding Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Interferon Production
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