GFER and MTRR

		GFER	MTRR
Description		growth factor, augmenter of liver regeneration	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol	Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Growth Factor Activity Protein-disulfide Reductase Activity Oxidoreductase Activity Flavin-dependent Sulfhydryl Oxidase Activity Thiol Oxidase Activity Flavin Adenine Dinucleotide Binding	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase (NADPH) Activity Flavin Adenine Dinucleotide Binding NADPH Binding FAD Binding Molecular Carrier Activity
	Biological Process	Liver Development Signal Transduction Mitochondrial Disulfide Relay System	Amino Acid Biosynthetic Process Methionine Biosynthetic Process Cobalamin Metabolic Process S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process
Pathways		Mitochondrial protein import	Methylation Sulfur amino acid metabolism Defective MTRR causes HMAE Defective MTR causes HMAG Cobalamin (Cbl) metabolism
Drugs		Flavin adenine dinucleotide	Cyanocobalamin Methionine
Diseases			Spina bifida Homocystinuria
GWAS			Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Interacting Genes		8 interacting genes: ASCC2 BNIPL COPS2 COPS5 PLEKHF2 SMAD2 TXN YY1	2 interacting genes: GMCL1 MMAB
Entrez ID		2671	4552
HPRD ID		02954	03979
Ensembl ID		ENSG00000127554	ENSG00000124275
Uniprot IDs		P55789	Q9UBK8
PDB IDs		3MBG 3O55 3TK0 3U2L 3U2M 3U5S 4LDK	2QTL 2QTZ
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation COP9 Signalosome SMAD Binding Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase (NADPH) Activity Protein-L-histidine N-pros-methyltransferase Activity	Flavin-dependent Sulfhydryl Oxidase Activity Mitochondrial Disulfide Relay System Corrinoid Adenosyltransferase Activity Thiol Oxidase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Cobalamin Binding Cobalamin Metabolic Process Protein-disulfide Reductase Activity
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