FOXJ1 and FBXO22

		FOXJ1	FBXO22
Description		forkhead box J1	F-box protein 22
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm Cytosol Z Disc
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Intracellular Protein Localization Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Epithelial Cell Differentiation Ciliary Basal Body Organization Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nucleocytoplasmic Transport Cellular Response To Starvation Regulation Of Myotube Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Creatinine levels ( 29403010) Urate levels in obese individuals ( 25811787)
Interacting Genes		17 interacting genes: ATP10A CD79B CDK3 FBXO22 FKBP1A GATA6 NMRAL1 OIP5 PECAM1 PRKCA RFX2 RPUSD1 SLC37A3 SMURF2 THRA TRMT6 TWF2	3 interacting genes: FOXJ1 SERPINB7 SNAI1
Entrez ID		2302	26263
HPRD ID		03798	16437
Ensembl ID		ENSG00000129654	ENSG00000167196
Uniprot IDs		Q92949	Q8NEZ5
PDB IDs			8S7D 8S7E 8UA3 8UA6
Enriched GO Terms of Interacting Partners?			Left/right Pattern Formation Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Glomerular Parietal Epithelial Cell Development Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Platelet-derived Growth Factor Production Regulation Of Platelet-derived Growth Factor Production Metanephric Part Of Ureteric Bud Development Regionalization Negative Regulation Of Vitamin D Biosynthetic Process Ciliary Basal Body Organization Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Glomerular Mesangial Cell Proliferation Regulation Of Germinal Center Formation Pattern Specification Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cartilage Morphogenesis Regulation Of Vitamin Metabolic Process Positive Regulation Of Cell Proliferation Involved In Kidney Development Positive Regulation Of Tolerance Induction Sequence-specific DNA Binding Heterochromatin Organization Regulation Of Glomerular Mesangial Cell Proliferation Lung Epithelium Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Trophoblast Giant Cell Differentiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Tolerance Induction Tolerance Induction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Biosynthetic Process Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Regulation Of T Cell Differentiation In Thymus Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Bicellular Tight Junction Assembly Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Steroid Metabolic Process Cardiac Epithelial To Mesenchymal Transition
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