EPHA4 and ETS1

		EPHA4	ETS1
Description		EPH receptor A4	ETS proto-oncogene 1, transcription factor
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endosome Early Endosome Plasma Membrane Adherens Junction Cell Surface Postsynaptic Density Membrane Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Presynaptic Membrane Cell Projection Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Axonal Growth Cone Cell Body Synapse Postsynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding Protein Tyrosine Kinase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Glial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Negative Regulation Of Translation Corticospinal Tract Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Organization Regulation Of GTPase Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Translational Initiation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Innervation Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Cochlea Development Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Neuron Projection Guidance Synapse Pruning Neuron Projection Fasciculation Membraneless Organelle Assembly Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Modification Of Synaptic Structure Regulation Of Synapse Pruning	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Differentiation PML Body Organization Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of MiRNA Transcription Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells Somitogenesis	Oncogene Induced Senescence
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26394188) Blond vs. brown/black hair color ( 30531825) Brain imaging ( 20100581) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cortical surface area (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Entorhinal cortical volume ( 31530798) Face memory ( 31596458) Hair color ( 29662168) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Nose size ( 27182965) Paclitaxel-induced neuropathy ( 23776197) Rostral anterior cingulate cortex volume ( 31530798) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels in lean individuals ( 25811787)	Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Celiac disease ( 20190752 22057235 25920553 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Eczema ( 31361310) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Follicular lymphoma ( 25279986) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Granulocyte count ( 27863252) Height ( 31562340) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 31959993 30054594 29785010 29617998) Itch intensity from mosquito bite ( 28199695) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Manganese levels ( 26025379) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 27863252 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252 32888494) Psoriasis ( 25903422 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 30423114 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Self-reported allergy ( 23817569) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 19838193 20169177 23273568 28714469 27399966 26502338 26663301) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 30718926 30297969 30054458) Ulcerative colitis ( 28067908) White blood cell count ( 27863252 32888494)
Interacting Genes		20 interacting genes: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 ERBB2 ETS1 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF RNF5 SLA2 SRC TNS3	62 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B CBL CFP COP1 CREB1 CREBBP CYBC1 DAXX DNMT3L DPAGT1 EIF5B EP300 EPHA4 ETS2 FOS GATA3 GGA1 GGA2 GGA3 HMBS HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 QPRT RBBP6 RPL13A RUNX1T1 RUNX2 SLC37A4 SMAD3 SP1 SP100 SPI1 SPIRE1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		2043	2113
HPRD ID		03719	01260
Ensembl ID		ENSG00000116106	ENSG00000134954
Uniprot IDs		E9PG71 P54764	A8K725 B4DW78 P14921
PDB IDs		2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2 7OFV 9CY8	1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Activity Regulation Of Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation Neuron Projection Guidance Axon Guidance Protein Tyrosine Kinase Activity Neuron Projection Development Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Binding Regulation Of Developmental Process Positive Regulation Of Lipase Activity Cell Projection Organization Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation T Cell Costimulation Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Neuron Projection Development Signal Transduction Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Positive Regulation Of MAPK Cascade Transmembrane-ephrin Receptor Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Protein Kinase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Cell Differentiation Protein Phosphorylation	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Transcription Regulator Complex Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Identical Protein Binding Nucleus Macromolecule Metabolic Process DNA-binding Transcription Factor Activity DNA-templated Transcription Cellular Response To Growth Factor Stimulus Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Transcription Coactivator Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
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