TIGIT and B4GALT4

		TIGIT	B4GALT4
Description		T cell immunoreceptor with Ig and ITIM domains	beta-1,4-galactosyltransferase 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Golgi Membrane Extracellular Region Golgi Apparatus Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Signaling Receptor Activity Identical Protein Binding	N-acetyllactosamine Synthase Activity Protein Binding Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity UDP-galactosyltransferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Activation	Lactosylceramide Biosynthetic Process Carbohydrate Metabolic Process Protein Glycosylation Lipid Metabolic Process Membrane Lipid Metabolic Process Keratan Sulfate Proteoglycan Biosynthetic Process Glycosylation
Pathways			Keratan sulfate biosynthesis N-Glycan antennae elongation
Drugs			N-Acetylglucosamine
Diseases
GWAS			Clozapine-induced cytotoxicity ( 25656473) First year height change in growth hormone-treated short stature ( 32652002) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Survival in pancreatic cancer ( 28470677)
Interacting Genes		11 interacting genes: B4GALT4 CCDC191 GRAMD1C MAL NECTIN2 NECTIN3 NECTIN4 PLLP PVR QTRT2 ZDHHC23	4 interacting genes: GOLPH3 GOLPH3L POLE4 TIGIT
Entrez ID		201633	8702
HPRD ID		08804	04930
Ensembl ID		ENSG00000181847	ENSG00000121578
Uniprot IDs		Q495A1	B2RAZ5 B3KM35 E7ETS9 O60513
PDB IDs		3Q0H 3RQ3 3UCR 3UDW 5V52 7VYT 8JEL 8JEN 8JEO 8SZY
Enriched GO Terms of Interacting Partners?		Cell Adhesion Mediator Activity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Structural Constituent Of Myelin Sheath Virus Receptor Activity Cell Adhesion Molecule Binding Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Receptor Ligand Activity Positive Regulation Of Immune Response To Tumor Cell Cell-cell Contact Zone Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Cell-cell Adhesion Adherens Junction Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Establishment Of Protein Localization To Membrane Negative Regulation Of Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Negative Regulation Of Defense Response Membrane Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Sperm Mitochondrion Organization Lactosylceramide Biosynthetic Process Regulation Of Transcytosis TRNA-guanosine(34) Queuine Transglycosylase Activity TRNA Wobble Guanine Modification TRNA-guanine Transglycosylase Complex	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Post-Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Protein Localization To Plasma Membrane Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Protein Targeting Establishment Of Protein Localization To Membrane Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Epsilon DNA Polymerase Complex Positive Regulation Of Protein Transport Regulation Of Protein Secretion Response To Rapamycin Golgi Vesicle Transport Positive Regulation Of Secretion By Cell Vesicle Organization Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Lipid Binding Establishment Of Protein Localization To Organelle Golgi Ribbon Formation Cellular Response To Ether ATAC Complex Regulation Of Protein Transport Positive Regulation Of Protein Localization Negative Regulation Of Interleukin-12 Production Leukocyte Tethering Or Rolling DNA-directed DNA Polymerase Activity Response To Ether Localization Within Membrane Regulation Of Establishment Of Protein Localization Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Secretion By Cell
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