DUSP7 and CCR1

		DUSP7	CCR1
Description		dual specificity phosphatase 7	C-C motif chemokine receptor 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	MAPK Cascade Signal Transduction Peptidyl-tyrosine Dephosphorylation Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade	Dendritic Cell Chemotaxis Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Canonical NF-kappaB Signal Transduction Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS			Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Behcet's disease ( 23291587) Celiac disease ( 18311140 20190752 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Myocardial infarction ( 33532862) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		11 interacting genes: CCR1 CFTR CNKSR1 EEF1A1 EGLN3 GHR IL16 MAPK1 MAPK14 MAPK8 SPOP	44 interacting genes: A4GNT CCL13 CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CDC25A CREB3 CTNNB1 DAG1 DDX3Y DNAJB12 DUSP7 FAN1 GNA14 GNAI2 GRAMD1A HAS3 JAK1 KRT6A LETMD1 MBP NPM1 PLP2 PRNP PRSS50 PXMP2 QSOX1 SNCA STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2
Entrez ID		1849	1230
HPRD ID		04125	03101
Ensembl ID		ENSG00000164086	ENSG00000163823
Uniprot IDs		Q16829	P32246 Q5U003
PDB IDs		4Y2E	7VL8 7VL9 7VLA
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cytokine-mediated Signaling Pathway Protein Phosphatase Binding Response To Lipid Regulation Of Ossification Positive Regulation Of Neuroinflammatory Response Locomotion Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Chemotaxis Ficolin-1-rich Granule Lumen Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Regulation Of Inflammatory Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Inflammatory Response Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Regulation Of Chemotaxis Response To Cytokine Regulation Of Neuroinflammatory Response Lipopolysaccharide-mediated Signaling Pathway Response To Peptide Positive Regulation Of Interleukin-12 Production MAPK Cascade Positive Regulation Of Locomotion Response To Epidermal Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding JUN Phosphorylation Homeostatic Process Protein Metabolic Process Cellular Senescence Regulation Of Interleukin-12 Production Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Response To Lipopolysaccharide Cytoplasm Positive Regulation Of Establishment Of Protein Localization Response To Growth Factor Energy Homeostasis Positive Regulation Of Anion Channel Activity Regulation Of Cytokine Production Involved In Inflammatory Response Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding	CCR Chemokine Receptor Binding Chemokine Activity Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Eosinophil Migration Antimicrobial Humoral Response Cytokine-mediated Signaling Pathway CCR1 Chemokine Receptor Binding Humoral Immune Response Chemotaxis Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Inflammatory Response Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cell Migration Response To External Biotic Stimulus Cell-cell Signaling Defense Response To Symbiont Regulation Of Cell Motility Monocyte Chemotaxis Defense Response Signaling Defense Response To Other Organism Response To Stress Cell Communication Response To Other Organism Calcium Ion Homeostasis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Calcium Ion Transport Immune Response Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Immune System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis
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