DUSP4 and ATP1A3

		DUSP4	ATP1A3
Description		dual specificity phosphatase 4	ATPase Na+/K+ transporting subunit alpha 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity MAP Kinase Serine/threonine Phosphatase Activity	Nucleotide Binding Amyloid-beta Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Endoderm Formation Signal Transduction Dephosphorylation Negative Regulation Of MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Ouabain Bisacodyl Tegoprazan
Diseases			Primary torsion dystonia (PTD)
GWAS		Gestational age at birth (maternal effect) ( 28598419) Postoperative complication after cardiac surgery ( 30678657) Prostate cancer ( 33293427) Response to statin therapy ( 20339536) Spontaneous preterm birth (maternal effect) ( 28598419)	Brain morphology (MOSTest) ( 32665545) Meat-related diet ( 32066663)
Interacting Genes		21 interacting genes: APP ATP1A3 CRMP1 GORASP2 GRIN1 GRIN2D IDO1 LYSMD1 LYSMD2 LZTS2 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 NOXA1 PLEKHF2 TEPSIN TRAF1 ZNF426 ZNF655	11 interacting genes: ABCA4 ASH2L ATRX ATXN1 CASP8 DUSP4 LYPD3 PPFIA3 PRKD2 TRIM29 ZNF229
Entrez ID		1846	478
HPRD ID		04123	01666
Ensembl ID		ENSG00000120875	ENSG00000105409
Uniprot IDs		Q13115	M0R116 P13637 Q53ES0
PDB IDs		3EZZ	8D3U 8D3V 8D3W 8D3X 8D3Y
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cyclase Activity Intracellular Signaling Cassette Interleukin-34-mediated Signaling Pathway JUN Kinase Activity Ionotropic Glutamate Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential MAPK Cascade Regulation Of Golgi Inheritance Lipopolysaccharide-mediated Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Ligand-gated Ion Channel Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Response To Lipopolysaccharide NMDA Glutamate Receptor Activity Glutamate Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Inflammatory Response Response To Molecule Of Bacterial Origin NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Protein Serine Kinase Activity Cellular Response To Amino Acid Starvation Glial Cell Development Cellular Senescence Excitatory Chemical Synaptic Transmission Bergmann Glial Cell Differentiation Response To Amino Acid Starvation Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Mechanical Stimulus Regulation Of Immune Response Regulation Of Synaptic Plasticity Protein Serine/threonine Kinase Activity Neuron Projection Maintenance
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