DUSP4 and IDO1

		DUSP4	IDO1
Description		dual specificity phosphatase 4	indoleamine 2,3-dioxygenase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Cytosol Smooth Muscle Contractile Fiber Stereocilium Bundle
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity MAP Kinase Serine/threonine Phosphatase Activity	Tryptophan 2,3-dioxygenase Activity Electron Transfer Activity Oxidoreductase Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Endoderm Formation Signal Transduction Dephosphorylation Negative Regulation Of MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade	Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Type 2 Immune Response L-tryptophan Catabolic Process Inflammatory Response Female Pregnancy L-tryptophan Catabolic Process To Kynurenine Quinolinate Biosynthetic Process Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Multicellular Organismal Response To Stress Kynurenic Acid Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Swimming Behavior T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway	Tryptophan catabolism
Drugs			Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28598419) Postoperative complication after cardiac surgery ( 30678657) Prostate cancer ( 33293427) Response to statin therapy ( 20339536) Spontaneous preterm birth (maternal effect) ( 28598419)
Interacting Genes		21 interacting genes: APP ATP1A3 CRMP1 GORASP2 GRIN1 GRIN2D IDO1 LYSMD1 LYSMD2 LZTS2 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 NOXA1 PLEKHF2 TEPSIN TRAF1 ZNF426 ZNF655	11 interacting genes: ADRB3 APP DCTN6 DDX24 DUSP4 FBXL17 PPP1R16A RBPMS SFRP1 SLC20A2 TERF2IP
Entrez ID		1846	3620
HPRD ID		04123	00935
Ensembl ID		ENSG00000120875	ENSG00000131203
Uniprot IDs		Q13115	A0A348GSI3 P14902
PDB IDs		3EZZ	2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PU7 6PZ1 6R63 6UBP 6V52 6WJY 6WPE 6X5Y 7A62 7AH4 7AH5 7AH6 7B1O 7E0O 7E0P 7E0Q 7E0S 7E0T 7E0U 7M63 7M7D 7NGE 7P0N 7P0R 7RRB 7RRC 7RRD 7YXT 7Z2L 7ZV3 8ABX 8FUR 8I7L 8U5I 9ESB 9ESC 9ESE 9ESG
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cyclase Activity Intracellular Signaling Cassette Interleukin-34-mediated Signaling Pathway JUN Kinase Activity Ionotropic Glutamate Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential MAPK Cascade Regulation Of Golgi Inheritance Lipopolysaccharide-mediated Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Ligand-gated Ion Channel Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Response To Lipopolysaccharide NMDA Glutamate Receptor Activity Glutamate Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Inflammatory Response Response To Molecule Of Bacterial Origin NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Protein Serine Kinase Activity Cellular Response To Amino Acid Starvation Glial Cell Development Cellular Senescence Excitatory Chemical Synaptic Transmission Bergmann Glial Cell Differentiation Response To Amino Acid Starvation Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Mechanical Stimulus Regulation Of Immune Response Regulation Of Synaptic Plasticity Protein Serine/threonine Kinase Activity Neuron Projection Maintenance
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