DDT and ADORA2A

		DDT	ADORA2A
Description		D-dopachrome tautomerase	adenosine A2a receptor
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Extracellular Exosome	Intermediate Filament Plasma Membrane Membrane Axon Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Presynaptic Active Zone Glutamatergic Synapse
	Molecular Function	Dopachrome Isomerase Activity Cytokine Receptor Binding Lyase Activity D-dopachrome Decarboxylase Activity Phenylpyruvate Tautomerase Activity	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Calmodulin Binding Lipid Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Alpha-actinin Binding
	Biological Process	Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of Tumor Necrosis Factor Production Melanin Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade	Synaptic Transmission, Dopaminergic G Protein-coupled Adenosine Receptor Signaling Pathway Response To Amphetamine Regulation Of DNA-templated Transcription Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission, Cholinergic Central Nervous System Development Blood Coagulation Sensory Perception Locomotory Behavior Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Glutamate Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Norepinephrine Secretion Response To Purine-containing Compound Response To Caffeine Positive Regulation Of Synaptic Transmission, GABAergic Synaptic Transmission, Glutamatergic Positive Regulation Of Urine Volume Vasodilation Eating Behavior Negative Regulation Of Vascular Permeability Response To Alkaloid Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Alpha-beta T Cell Activation Astrocyte Activation Neuron Projection Morphogenesis Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Mitochondrial Membrane Potential Membrane Depolarization Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Prepulse Inhibition Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Signaling Pathway
Pathways			NGF-independant TRKA activation Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism
Drugs			Caffeine Theophylline Mefloquine Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Oxtriphylline Theobromine Binodenoson Defibrotide Apadenoson Atl146e Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol Doxofylline Istradefylline 8-chlorotheophylline KW-6356
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)	Acne (severe) ( 24927181) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption (cups per day) ( 31217584) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		1 interacting genes: ADORA2A	32 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 ADA BET1 CD4 CDH2 CHN1 CNR1 CYTH2 DDT DRD2 FZD3 GGT1 GGT5 GPR37 HNRNPH3 HRH3 NAMPT NECAB2 PDHB POMZP3 PPM1J RHBDD2 RHOB SLC25A39 SLC35A2 SLC4A1AP SNCA SPNS1 SYNGR1
Entrez ID		1652	135
HPRD ID		04126	00043
Ensembl ID		ENSG00000099977	ENSG00000128271
Uniprot IDs		B5MC82 P30046 Q53Y51	A8K1F6 B3KVQ4 P29274 X5DNB4
PDB IDs		1DPT 3KAN 4Q3F 6C5F 7MRU 7MRV 7MSE 7MW7 8DBB 8VDY 8VFK 8VFL 8VFN 8VFO 8VFW 8VG5 8VG7 8VG8 9BB0	2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6LPJ 6LPK 6LPL 6MH8 6PS7 6S0L 6S0Q 6WQA 6ZDR 6ZDV 7ARO 7EZC 7PX4 7PYR 7RM5 7T32 8A2O 8A2P 8C9W 8CIC 8CU6 8CU7 8DU3 8GNE 8GNG 8JWY 8JWZ 8PWN 8RQQ 8RVW 8RW0 8RW4 8RW7 8RWC 8RWD 8RWE 8RWH 8RWI 8RWX 8UGW 8WDT 9FUP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neurotransmitter Secretion Regulation Of Norepinephrine Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Circadian Rhythm Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Urine Volume Synaptic Transmission, Dopaminergic Prepulse Inhibition Inhibitory Postsynaptic Potential Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Urine Volume Synaptic Transmission, Cholinergic Positive Regulation Of Long-term Synaptic Potentiation Astrocyte Activation G Protein-coupled Adenosine Receptor Activity Asymmetric Synapse Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Axolemma Alpha-actinin Binding Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Amino Acid Transport Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Response To Caffeine G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Positive Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Positive Regulation Of Behavior Eating Behavior Response To Amphetamine Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, GABAergic Presynaptic Active Zone Regulation Of Catecholamine Secretion Presynaptic Modulation Of Chemical Synaptic Transmission Blood Circulation Regulation Of Long-term Synaptic Potentiation Synaptic Transmission, Glutamatergic Response To Amine Regulation Of Vascular Permeability Negative Regulation Of Alpha-beta T Cell Activation Cellular Defense Response Membrane Depolarization Vasodilation Excitatory Postsynaptic Potential Regulation Of Mitochondrial Membrane Potential Regulation Of Synaptic Transmission, Glutamatergic	Pseudopodium Cortical Actin Cytoskeleton Cell Junction Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Synapse Actin Cytoskeleton Plasma Membrane Focal Adhesion Assembly Positive Regulation Of MAPK Cascade Phenol-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of ERK1 And ERK2 Cascade Dopamine Metabolic Process Muscle Cell Development Response To Iron Ion Leukotriene C4 Gamma-glutamyl Transferase Activity Cell-substrate Junction Assembly Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Cell-substrate Junction Organization Presynapse Catecholamine Metabolic Process Glutathione Hydrolase Activity Leukotriene D4 Biosynthetic Process Fascia Adherens Negative Regulation Of Oxidative Phosphorylation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Calcium Ion Binding Transmembrane Transporter Binding Focal Adhesion Z Disc Cell Junction Assembly Negative Regulation Of Cellular Respiration Glutathione Catabolic Process Dopamine Biosynthetic Process Postsynaptic Actin Cytoskeleton Regulation Of Intracellular Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Glutathione Metabolic Process Positive Regulation Of Intracellular Signal Transduction Integrin Binding Sarcomere Cell Junction Organization Response To Inactivity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Neuronal Synaptic Plasticity Catecholamine Uptake
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