CSF2 and IKBKE

		CSF2	IKBKE
Description		colony stimulating factor 2	inhibitor of nuclear factor kappa B kinase subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Mitochondrial Membrane Serine/threonine Protein Kinase Complex
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Histamine Secretion Embryonic Placenta Development Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Epithelial Fluid Transport Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of DNA-templated Transcription Regulation Of Developmental Process Positive Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Activation Of Innate Immune Response Response To Stress Immune Response DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Positive Regulation Of Lipid Storage Positive Regulation Of Type I Interferon Production Response To Cytokine Response To Type I Interferon Response To Interferon-beta Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly MRNA Stabilization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Virus
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	SUMOylation of immune response proteins TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		KB002	Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Rheumatoid arthritis ( 22446963 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966 33272962)
Interacting Genes		17 interacting genes: CSF2RA CSF2RB DPP7 ETF1 FBN2 IKBKE IL3RA KITLG MEOX2 P2RX7 PRG2 S100A6 S100P SDC2 SEMA7A TAGLN TREML2	26 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CSF2 CYLD DAXX DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP MUC1 NFKBIA PTGFR RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP
Entrez ID		1437	9641
HPRD ID		00734	05442
Ensembl ID		ENSG00000164400	ENSG00000263528
Uniprot IDs		P04141	A0A075B7B4 Q14164
PDB IDs		1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS
Enriched GO Terms of Interacting Partners?		Interleukin-3 Receptor Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Macrophage Cytokine Production Cytokine Receptor Activity External Side Of Plasma Membrane Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Extracellular Matrix Signaling Receptor Activity Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cytokine Binding Positive Regulation Of Bone Mineralization Translation Termination Factor Activity Cytoplasmic Translational Termination Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Apoptotic Process Positive Regulation Of Biomineral Tissue Development Immune System Process Positive Regulation Of Ossification Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Cell Population Proliferation	Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Regulation Of Post-translational Protein Modification Regulation Of Defense Response Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To External Biotic Stimulus Innate Immune Response-activating Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Response To Stress Response To Virus Regulation Of Apoptotic Process Regulation Of Immune Response Activation Of Immune Response Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Protein Ubiquitination Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Non-canonical NF-kappaB Signal Transduction Defense Response Immune Response-activating Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Response To Other Organism Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Canonical NF-kappaB Signal Transduction
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