TRMT61A and COA8

		TRMT61A	COA8
Description		tRNA methyltransferase 61A	cytochrome c oxidase assembly factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity	Protein Binding
	Biological Process	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation	Response To Reactive Oxygen Species Apoptotic Process Mitochondrial Cytochrome C Oxidase Assembly Protein Stabilization Intrinsic Apoptotic Signaling Pathway
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494) Schizophrenia ( 25056061)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		2 interacting genes: TCL1A TRMT6
Entrez ID		115708	84334
HPRD ID		08810	12637
Ensembl ID		ENSG00000166166	ENSG00000256053
Uniprot IDs		Q96FX7	A0A6Q8JUI0 G3V4L6 Q96IL0
PDB IDs		5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?			MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body
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