TWF2 and MANF

		TWF2	MANF
Description		twinfilin actin binding protein 2	mesencephalic astrocyte derived neurotrophic factor
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Myofibril Lamellipodium Filopodium Growth Cone Stereocilium Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Sarcoplasmic Reticulum Sarcoplasmic Reticulum Lumen
	Molecular Function	RNA Binding Actin Binding Actin Monomer Binding Protein Kinase C Binding Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Anion Binding Cadherin Binding Actin Filament Binding	RNA Binding Protein Binding Growth Factor Activity Lipid Binding Sulfatide Binding
	Biological Process	Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Cell Projection Organization Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Axon Extension Barbed-end Actin Filament Capping Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus	Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Response To Unfolded Protein Neuron Projection Development ATF6-mediated Unfolded Protein Response Dopaminergic Neuron Differentiation Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Platelet degranulation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Schizophrenia ( 23974872)	Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Diverticular disease ( 30177863)
Interacting Genes		12 interacting genes: ARHGDIA CEBPA CHGB COXFA4L3 FAM107A FOXJ1 ILK MANF NISCH POT1 STAB1 TERF2IP	3 interacting genes: RRP9 TWF2 ZDHHC17
Entrez ID		11344	7873
HPRD ID		08464	03558
Ensembl ID		ENSG00000247596	ENSG00000145050
Uniprot IDs		Q6IBS0	A8K878 P55145
PDB IDs		2VAC 2W0I	2KVD 2KVE 2W51
Enriched GO Terms of Interacting Partners?		Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Intracellular Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glomerular Parietal Epithelial Cell Development Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Central B Cell Tolerance Induction Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Osteoblast Differentiation Response To Vitamin B2 C/EBP Complex Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere Rho GDP-dissociation Inhibitor Activity CHOP-C/EBP Complex Protein Localization To Cell Cortex DNA Biosynthetic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Intracellular Signaling Cassette Regulation Of Non-canonical NF-kappaB Signal Transduction Telomere Maintenance Positive Regulation Of Chromosome Organization White Fat Cell Proliferation Metanephric Part Of Ureteric Bud Development Regulation Of Telomere Maintenance Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Hemopoiesis Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Ciliary Basal Body Organization Single-stranded Telomeric DNA Binding Telomere Organization	Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Box C/D Methylation Guide SnoRNP Complex Regulation Of Microvillus Length Anion Binding Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity U3 SnoRNA Binding Actin Filament Depolymerization Regulation Of Cell Projection Size Barbed-end Actin Filament Capping Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity SnoRNA Binding Actin Monomer Binding Positive Regulation Of Lamellipodium Assembly Protein Lipidation Positive Regulation Of Lamellipodium Organization Actin Filament Capping Regulation Of Lamellipodium Assembly Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Axon Extension Protein Depolymerization
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