TCIRG1 and DNAH3

		TCIRG1	DNAH3
Description		T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	dynein axonemal heavy chain 3
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Nucleus Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Secretory Granule Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Phagocytic Vesicle Ficolin-1-rich Granule Membrane	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Dynein Complex Inner Dynein Arm Cell Projection 9+2 Motile Cilium
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Autophagosome Assembly Ossification Osteoclast Proliferation Monoatomic Ion Transport Intracellular Calcium Ion Homeostasis Autophagy Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Lysosomal Lumen Acidification Positive Regulation Of Cell Population Proliferation Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity Myeloid Cell Differentiation B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Memory T Cell Activation T-helper 1 Cell Activation Odontogenesis T Cell Homeostasis Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation PH Reduction Homeostasis Of Number Of Cells Regulation Of Insulin Secretion Intracellular PH Reduction Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport	Cilium Movement Microtubule-based Movement Inner Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Heel bone mineral density ( 30598549) Reticulocyte count ( 32888494)	Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494) Immune reponse to smallpox (secreted IL-10) ( 22610502) Plateletcrit ( 32888494) Resting-state electroencephalogram vigilance ( 29703947) Serum uric acid levels ( 29559957) Systolic blood pressure ( 27841878)
Interacting Genes		8 interacting genes: CYTH2 DNAH3 HSP90AA1 KCNK1 MTDH POGZ TERF1 TLX3	7 interacting genes: ERI2 IVL NPIPB3 REXO5 SOD1 TCIRG1 THUMPD1
Entrez ID		10312	55567
HPRD ID		05207	04513
Ensembl ID		ENSG00000110719	ENSG00000158486
Uniprot IDs		Q13488	A0A8V8TLI9 B4E1S1 Q8TD57
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Brush Border Membrane Apical Plasma Membrane CTP Binding Chromosome Organization DATP Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly DNA Biosynthetic Process Telomere Maintenance Neurofibrillary Tangle Assembly UTP Binding Regulation Of DNA Biosynthetic Process Sulfonylurea Receptor Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Rho GDP-dissociation Inhibitor Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Bicellular Tight Junction Telomere Organization Ligand-gated Channel Activity Neuron Migration Sperm Mitochondrial Sheath Inward Rectifier Potassium Channel Complex Fibrillar Center Inner Dynein Arm Telomerase Holoenzyme Complex Assembly Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Intercellular Canaliculus Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction DNA Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Protein-containing Complex Assembly Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Potassium Channel Complex Regulation Of Establishment Of Protein Localization To Chromosome	Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Dentin Mineralization Response To Silver Ion Exonuclease Activity Response To Antipsychotic Drug Action Potential Initiation Memory T Cell Activation
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