THOC1

Description		THO complex subunit 1
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GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	DNA Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA Transport
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)
Novel Interacting Genes		34 novel interacting genes: AGR2 AKAP9 ATP1B1 CTAG1A CTAG1B DHX8 ESS2 EXOC5 EXOSC7 FRA10AC1 GPRASP3 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C PRC1 PRPF6 RABGEF1 RB1 REL SAP30BP SF3B2 SNW1 TADA2A TFIP11 TRIM27 TRIM54 TYMS USHBP1 WDR77 ZMYND12
Interacting Genes		34 interacting genes: AGR2 AKAP9 ATP1B1 CTAG1A CTAG1B DHX8 ESS2 EXOC5 EXOSC7 FRA10AC1 GPRASP3 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C PRC1 PRPF6 RABGEF1 RB1 REL SAP30BP SF3B2 SNW1 TADA2A TFIP11 TRIM27 TRIM54 TYMS USHBP1 WDR77 ZMYND12
Entrez ID		9984
HPRD ID		09498
Ensembl ID		ENSG00000079134
Uniprot IDs		Q96FV9
PDB IDs		1WXP 7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome Spliceosomal Complex RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing Cyclin/CDK Positive Transcription Elongation Factor Complex U2-type Precatalytic Spliceosome
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