EXOG

Description		exo/endonuclease G
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Protein-containing Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Nucleic Acid Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Apoptotic DNA Fragmentation
Pathways		Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Appendicular lean mass ( 33097823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) P wave duration ( 24850809) PR interval ( 25035420) QRS duration ( 25035420 27577874)
Novel Interacting Genes		1 novel interacting genes: FOXP1
Interacting Genes		1 interacting genes: FOXP1
Entrez ID		9941
HPRD ID		06813
Ensembl ID		ENSG00000157036
Uniprot IDs		Q9Y2C4
PDB IDs		4A1N 5T3V 5T40 5T4I 5T5C 5ZKI 5ZKJ 6IID 7R6T 7R6V 9FXN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-21 Production Monocyte Activation Regulation Of Defense Response To Bacterium Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Osteoclast Development Negative Regulation Of Androgen Receptor Signaling Pathway Striatum Development Positive Regulation Of B Cell Receptor Signaling Pathway Endothelial Cell Activation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Monocyte Differentiation T Follicular Helper Cell Differentiation Core Promoter Sequence-specific DNA Binding Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of B Cell Apoptotic Process Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Tissue Growth Nuclear Androgen Receptor Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation T-helper Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Muscle Hypertrophy Response To Testosterone Negative Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Organ Growth Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy T Cell Differentiation Involved In Immune Response Osteoclast Differentiation CD4-positive, Alpha-beta T Cell Differentiation T Cell Activation Involved In Immune Response Regulation Of Heart Growth Macrophage Activation Alpha-beta T Cell Differentiation Forebrain Development Regulation Of Lymphocyte Apoptotic Process CD4-positive, Alpha-beta T Cell Activation Regulation Of Morphogenesis Of An Epithelium Myeloid Cell Development Negative Regulation Of Muscle Cell Differentiation Regulation Of Interleukin-12 Production Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation
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