MAFB

Description		MAF bZIP transcription factor B
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Segment Specification Sensory Organ Development Response To Nutrient Respiratory Gaseous Exchange By Respiratory System Gene Expression Protein Processing Rhombomere 5 Development Rhombomere 6 Development Abducens Nerve Formation Keratinocyte Differentiation T Cell Differentiation In Thymus Brain Segmentation Inner Ear Morphogenesis Fat Cell Differentiation Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Integrated Stress Response Signaling Cornified Envelope Assembly
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 30172743) Cholesterol, total ( 20686565 24097068 25961943) Cognitive decline rate in late mild cognitive impairment ( 26252872) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Dupuytren's disease ( 21732829 28886342) Height ( 25282103) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 25961943 24097068 20686565 19060906) LDL cholesterol levels ( 28334899 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Obesity-related traits ( 23251661) Paneth cell defects in Crohn's disease ( 28352666) Plasma parathyroid hormone levels ( 30134803) QT interval (ambient particulate matter interaction) ( 28749367) Red blood cell count ( 32888494) Response to TNF antagonist treatment ( 18615156) Serum alkaline phosphatase levels ( 33547301) Serum total protein levels ( 29403010) Spleen volume ( 34128465) Total body bone mineral density ( 29304378) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		12 novel interacting genes: ATF4 BACH1 FOS FOSL1 HOXD12 JUN KRTAP4-2 MAF STK4 ZDHHC2 ZFP64 ZWINT
Interacting Genes		12 interacting genes: ATF4 BACH1 FOS FOSL1 HOXD12 JUN KRTAP4-2 MAF STK4 ZDHHC2 ZFP64 ZWINT
Entrez ID		9935
HPRD ID		07129
Ensembl ID		ENSG00000204103
Uniprot IDs		Q9Y5Q3
PDB IDs
Enriched GO Terms of Interacting Partners?		Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Sequence-specific Double-stranded DNA Binding Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Transcription Factor AP-1 Complex Positive Regulation Of MiRNA Metabolic Process Promoter-specific Chromatin Binding DNA Binding Transcription Regulator Complex Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding General Transcription Initiation Factor Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hemopoiesis Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Protein Signal Transduction Response To Muscle Stretch R-SMAD Binding Intracellular Signaling Cassette Cellular Response To Metal Ion Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Myeloid Cell Differentiation Transcription Cis-regulatory Region Binding Medium-term Memory Cellular Response To Prolactin Positive Regulation Of Hepatocyte Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process
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