PAN2

Description		poly(A) specific ribonuclease subunit PAN2
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol PAN Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Cysteine-type Deubiquitinase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly
Pathways		Deadenylation of mRNA
Drugs
Diseases
GWAS		Axial length ( 24144296) Height ( 25429064 34054925 34270706) Refractive error ( 32231278)
Novel Interacting Genes		9 novel interacting genes: ATM DYNLL1 PABPC1 PAN3 RBBP8 RBCK1 RNF144B TNRC6A TRIM35
Interacting Genes		9 interacting genes: ATM DYNLL1 PABPC1 PAN3 RBBP8 RBCK1 RNF144B TNRC6A TRIM35
Entrez ID		9924
HPRD ID		15640
Ensembl ID		ENSG00000135473
Uniprot IDs		Q504Q3
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Strand Resection Involved In Replication Fork Processing Site Of Double-strand Break Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Poly(A) Binding DNA Double-strand Break Processing Macromolecule Catabolic Process Positive Regulation Of Catabolic Process RNA Catabolic Process Protein Ubiquitination Homologous Recombination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Catabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Ubiquitin Protein Ligase Activity Regulation Of MRNA Metabolic Process Apoptotic Process Establishment Of RNA Localization To Telomere Negative Regulation Of Metabolic Process Establishment Of Protein-containing Complex Localization To Telomere Programmed Cell Death Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cell Death Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing PAN Complex Positive Regulation Of Organelle Assembly Positive Regulation Of RNA Metabolic Process P-body Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Catabolic Process Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Gene Expression Response To Stress
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