MELK

Description		maternal embryonic leucine zipper kinase
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation
Pathways
Drugs		Fostamatinib
Diseases
GWAS
Novel Interacting Genes		11 novel interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622
Interacting Genes		11 interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622
Entrez ID		9833
HPRD ID		06119
Ensembl ID		ENSG00000165304
Uniprot IDs		B7Z1G6 Q14680
PDB IDs		4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC 5K00 5M5A 5MAF 5MAG 5MAH 5MAI 5TVT 5TWL 5TWU 5TWY 5TWZ 5TX3 6GVX 6VXR 9F31
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus Nuclear Periphery Double-stranded DNA Binding Spliceosomal Complex Nucleoplasm Stress Granule Assembly Translation Initiation Ternary Complex Cellular Response To Chemical Stress Cellular Response To Heat Cellular Response To Oxidative Stress Hepatocyte Homeostasis Chromatin Remodeling Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Positive Regulation Of Metalloendopeptidase Activity Ribonuclease E Activity U11/U12 SnRNP Positive Regulation Of Catalytic Activity RNA Splicing Catalytic Step 2 Spliceosome Response To Heat Response To Oxidative Stress Chromatin DNA Binding Cellular Response To Trichostatin A Chromatin Organization Structural Constituent Of Nuclear Lamina Neurofibrillary Tangle Assembly Nuclear Speck Regulation Of Gene Expression MRNA Processing Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Response To Kainic Acid Eukaryotic Translation Initiation Factor 2 Complex Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Hydrolase Activity Cellular Response To Reactive Oxygen Species Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Regulation Of Metallopeptidase Activity Internode Region Of Axon Compact Myelin Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translational Initiation In Response To Stress
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