PIEZO1

Description		piezo type mechanosensitive ion channel component 1 (Er blood group)
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Lamellipodium Membrane Stereocilium Cuticular Plate Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection
	Molecular Function	Monoatomic Cation Channel Activity Protein Binding Mechanosensitive Monoatomic Ion Channel Activity Mechanosensitive Monoatomic Cation Channel Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Positive Regulation Of Myotube Differentiation Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Detection Of Mechanical Stimulus Cellular Response To Mechanical Stimulus Monoatomic Cation Transmembrane Transport
Pathways		High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Diverticular disease ( 30177863) Glycated hemoglobin levels ( 34059833) Hair color ( 26926045) Heel bone mineral density ( 30598549) Height ( 28552196 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Joint mobility (Beighton score) ( 27182965) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 28453575 27863252 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494) Remission after antidepressant treatment in major depression ( 33589590) Response to antidepressants (symptom improvement) ( 33589590) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Triglyceride levels in HIV infection ( 33109212) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: TUBB3
Interacting Genes		1 interacting genes: FBXO7
Entrez ID		9780
HPRD ID		10945
Ensembl ID		ENSG00000103335
Uniprot IDs		Q92508
PDB IDs		8YEZ 8YFC 8YFG 8ZU3 8ZU8
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Netrin Receptor Binding Lewy Body Core Dorsal Root Ganglion Development Netrin-activated Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Ganglion Development Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Peptide Binding Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
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