SLK

Description		STE20 like kinase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Apoptotic Process Regulation Of Cell Migration Cytoplasmic Microtubule Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Focal Adhesion Assembly
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		K-00546 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 29403010) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Pulse pressure ( 30487518) Systolic blood pressure ( 30487518) Uterine fibroids ( 21460842 31649266)
Novel Interacting Genes		3 novel interacting genes: CASP3 CLSTN1 PDZK1
Interacting Genes		3 interacting genes: CASP3 CLSTN1 PDZK1
Entrez ID		9748
HPRD ID		11585
Ensembl ID		ENSG00000065613
Uniprot IDs		Q9H2G2
PDB IDs		2J51 2JFL 2JFM 2UV2 4USF 6HVD 8BEM
Enriched GO Terms of Interacting Partners?		Response To Anesthetic Anterior Neural Tube Closure Postsynaptic Density Protein-containing Complex Binding Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Death-inducing Signaling Complex Luteolysis Glial Cell Apoptotic Process Phospholipase A2 Activator Activity Protein Localization To Cell Periphery Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Protein Localization To Membrane X11-like Protein Binding Postsynaptic Endosome Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Fibroblast Apoptotic Process Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Regulation Of Synaptic Vesicle Cycle Interleukin-18-mediated Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Quaternary Ammonium Group Transport Neurotransmitter Receptor Transport Localization Within Membrane Negative Regulation Of B Cell Proliferation Death Receptor Binding Glutamatergic Synapse Protein Poly-ADP-ribosylation Positive Regulation Of Amyloid-beta Formation Aspartic-type Endopeptidase Activity Axonal Fasciculation Neuron Projection Fasciculation Platelet Formation Neurotrophin Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process Response To X-ray Execution Phase Of Apoptosis Microvillus Membrane
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