HERPUD1

Description		homocysteine inducible ER protein with ubiquitin like domain 1
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Lewy Body Core
	Molecular Function	Protein Binding Transmembrane Transporter Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Calcium Ion Homeostasis Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress ERAD Pathway Protein Targeting To ER Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Hip circumference adjusted for BMI ( 34021172) Hypo-HDL-cholesterolemia ( 31087446) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 33339817) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Serum metabolite levels ( 33031748) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Novel Interacting Genes		19 novel interacting genes: AMFR APP ARHGDIA C5AR2 CCR2 CD3D CD58 CHRM2 EWSR1 F2RL1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 XRCC6
Interacting Genes		19 interacting genes: AMFR APP ARHGDIA C5AR2 CCR2 CD3D CD58 CHRM2 EWSR1 F2RL1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 XRCC6
Entrez ID		9709
HPRD ID		07456
Ensembl ID		ENSG00000051108
Uniprot IDs		A4UAE9 Q15011 Q53FP9
PDB IDs		1WGD
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Signal Transduction Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Astrocyte Activation Involved In Immune Response Regulation Of Immune Response Regulation Of Tumor Necrosis Factor Production Regulation Of Proteolysis Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune System Process Regulation Of Chemotaxis Positive Regulation Of Protein Catabolic Process Positive Regulation Of Type II Interferon Production Immune System Process Positive Regulation Of Immune Response Regulation Of Proteasomal Protein Catabolic Process Neuron Projection Maintenance Regulation Of Leukocyte Migration Dendrite Protein-containing Complex Regulation Of Synaptic Vesicle Cycle Regulation Of Interleukin-8 Production Response To Stress Regulation Of Immune System Process Positive Regulation Of Leukocyte Chemotaxis Autophagosome Assembly Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Amyloid Fibril Formation Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Cytokine Production Autophagosome Organization Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Superoxide Anion Generation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Catabolic Process Regulation Of Type II Interferon Production Positive Regulation Of Monocyte Chemotaxis Leukocyte Activation Positive Regulation Of Glycolytic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Myeloid Leukocyte Activation Early Endosome
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