PTGES

Description		prostaglandin E synthase
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GO Annotations	Cellular Component	Nuclear Envelope Lumen Cytoplasm Endoplasmic Reticulum Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Prostaglandin-D Synthase Activity Protein Binding Oxidoreductase Activity Transferase Activity Isomerase Activity Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Signal Transduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Sensory Perception Of Pain Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Regulation Of Inflammatory Response Cellular Oxidant Detoxification
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS		Asthma ( 27611488) Pars orbitalis volume ( 31530798) Type 1 diabetes (age at diagnosis) ( 33179336)
Novel Interacting Genes		18 novel interacting genes: ARLN BET1 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A
Interacting Genes		18 interacting genes: ARLN BET1 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A
Entrez ID		9536
HPRD ID		05528
Ensembl ID		ENSG00000148344
Uniprot IDs		O14684
PDB IDs		3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9 6VL4 8PYV
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport SNAP Receptor Activity Prostaglandin E Receptor Activity SNARE Complex Endoplasmic Reticulum SNARE Complex Assembly Transport Vesicle Vesicle Organization Organelle Fusion Response To Prostaglandin E Membrane Fusion Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization To Plasma Membrane Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Presynaptic Endosome Membrane Golgi To Plasma Membrane Transport Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum Unfolded Protein Response Clathrin-coated Endocytic Vesicle Membrane Cellular Response To Type II Interferon Synaptic Vesicle To Endosome Fusion FFAT Motif Binding Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Prostaglandin Receptor Activity Cellular Localization Protein Transport Golgi Membrane Phagocytic Vesicle Establishment Of Localization In Cell Membrane Organization Response To Unfolded Protein Membrane Docking Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Response To Type II Interferon Post-Golgi Vesicle-mediated Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Membrane Fusion Vesicle Fusion (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Trans-Golgi Network Membrane Host-mediated Perturbation Of Viral RNA Genome Replication
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