ADAMTS3

Description		ADAM metallopeptidase with thrombospondin type 1 motif 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	In Utero Embryonic Development Proteolysis Vascular Endothelial Growth Factor Production Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Biosynthetic Process Supramolecular Fiber Organization Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		Collagen biosynthesis and modifying enzymes Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholesterol ester levels in large LDL ( 29084231) Cholesterol ester levels in medium LDL ( 29084231) Cholesterol, total ( 25961943) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23259602) Dialysis-related mortality ( 21546767) Glycine levels ( 31070104) Height ( 25429064 25282103 31562340 28552196 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Hippocampal volume ( 29274321) Hippocampal volume in mild cognitive impairment ( 29274321) Large LDL particle concentration ( 29084231) Medium LDL particle concentration ( 29084231) Metabolite levels ( 22916037) Serum total cholesterol levels ( 29084231) Small LDL particle concentration ( 29084231) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels in large LDL ( 29084231) Total cholesterol levels in LDL ( 29084231) Total cholesterol levels in medium LDL ( 29084231) Total cholesterol levels in small LDL ( 29084231) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 26785701 34021172)
Novel Interacting Genes		1 novel interacting genes: UBQLN2
Interacting Genes		1 interacting genes: UBQLN2
Entrez ID		9508
HPRD ID		06893
Ensembl ID		ENSG00000156140
Uniprot IDs		B7Z2U9 O15072 Q96AY5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Regulation Of ERAD Pathway Negative Regulation Of Receptor-mediated Endocytosis Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Autophagosome Assembly Molecular Condensate Scaffold Activity Regulation Of Vacuole Organization Negative Regulation Of Endocytosis Autophagosome Regulation Of Receptor Internalization Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Vacuole Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Response To Endoplasmic Reticulum Stress Regulation Of Organelle Assembly
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