SLC4A8

Description		solute carrier family 4 member 8
Image
GO Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Terminal Bouton Axon Terminus Synapse Glial Cell Projection Hippocampal Mossy Fiber Presynapse Glutamatergic Synapse
	Molecular Function	Solute:inorganic Anion Antiporter Activity Zinc Ion Binding Monoatomic Anion Transmembrane Transporter Activity Sodium:bicarbonate Symporter Activity Sodium Ion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding Sodium,bicarbonate:chloride Antiporter Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Monoatomic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Regulation Of Intracellular PH Transmembrane Transport Basolateral Protein Secretion Transport Across Blood-brain Barrier Chloride Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Synaptic Vesicle Exocytosis
Pathways		Bicarbonate transporters
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Fruit consumption ( 32066663) Problematic alcohol use ( 32451486) Response to antidepressants and depression ( 27622933) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Novel Interacting Genes		3 novel interacting genes: CA2 CFTR NHERF1
Interacting Genes		3 interacting genes: CA2 CFTR NHERF1
Entrez ID		9498
HPRD ID		05430
Ensembl ID		ENSG00000050438
Uniprot IDs		Q2Y0W8
PDB IDs		5JHO
Enriched GO Terms of Interacting Partners?		Chloride Channel Regulator Activity Regulation Of Monoatomic Anion Transport Regulation Of Monoatomic Ion Transport Intracellular Chemical Homeostasis Cellular Homeostasis Apical Part Of Cell Regulation Of Cellular PH Regulation Of Intracellular PH PDZ Domain Binding Regulation Of PH Chemical Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Renal Phosphate Ion Absorption Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity Positive Regulation Of Anion Channel Activity Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Homeostatic Process Positive Regulation Of Monoatomic Anion Transport Type 3 Metabotropic Glutamate Receptor Binding Anatomical Structure Morphogenesis Positive Regulation Of Enamel Mineralization Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Transport Regulation Of Chloride Transport Transepithelial Water Transport Growth Factor Receptor Binding Positive Regulation Of Cell Communication Morphogenesis Of An Epithelium Positive Regulation Of Signaling Positive Regulation Of Tooth Mineralization Organic Anion Transport Chloride Channel Inhibitor Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Gamma-aminobutyric Acid Import Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Apical Plasma Membrane
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