GGPS1

Description		geranylgeranyl diphosphate synthase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Dimethylallyltranstransferase Activity Geranylgeranyl Diphosphate Synthase Activity (2E,6E)-farnesyl Diphosphate Synthase Activity Prenyltransferase Activity Protein Binding Transferase Activity Identical Protein Binding Metal Ion Binding Prenyl Diphosphate Synthase Activity
	Biological Process	Lipid Metabolic Process Isoprenoid Metabolic Process Isoprenoid Biosynthetic Process Geranyl Diphosphate Biosynthetic Process Geranylgeranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Pamidronic acid Zoledronic acid Ibandronate Geranyl Diphosphate Farnesyl thiopyrophosphate ISOPENTENYL PYROPHOSPHATE Minodronic acid (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate Lauryl alcohol diphosphonic acid (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)
Diseases
GWAS		Asthma ( 29273806)
Novel Interacting Genes		3 novel interacting genes: ATOX1 MX1 SDCBP
Interacting Genes		3 interacting genes: ATOX1 MX1 SDCBP
Entrez ID		9453
HPRD ID		06099
Ensembl ID		ENSG00000152904
Uniprot IDs		O95749
PDB IDs		2Q80 6C56 6C57 6G31 6G32 6R4V 9CSL
Enriched GO Terms of Interacting Partners?		Copper-dependent Protein Binding Copper Ion Export Copper Chaperone Activity Metallochaperone Activity Nuclear Membrane Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Extracellular Exosome Assembly Copper Ion Transmembrane Transport Interleukin-27-mediated Signaling Pathway Cuprous Ion Binding Substrate-dependent Cell Migration, Cell Extension Response To Type I Interferon Intracellular Copper Ion Homeostasis Copper Ion Transport Negative Regulation Of Receptor Internalization Positive Regulation Of Exosomal Secretion Copper Ion Homeostasis Regulation Of Exosomal Secretion Cytoskeletal Anchor Activity
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