LY86

Description		lymphocyte antigen 86
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GO Annotations	Cellular Component	Extracellular Region
	Molecular Function	Protein Binding
	Biological Process	Immune System Process Inflammatory Response Immune Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response
Pathways		Toll Like Receptor 4 (TLR4) Cascade
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FEV1/FVC) ( 30804560 30175238) Major depressive disorder (broad) ( 20038947) Multiple sclerosis ( 31604244) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum uric acid levels ( 30993211) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134) Urate levels in overweight individuals ( 25811787) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Waist-hip ratio ( 25673412 23966867 23563607 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Novel Interacting Genes		1 novel interacting genes: STAT4
Interacting Genes		2 interacting genes: CD180 GEMIN4
Entrez ID		9450
HPRD ID		05578
Ensembl ID		ENSG00000112799
Uniprot IDs		O95711
PDB IDs		3B2D
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Involved In Immune Response Lymphocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Immune Effector Process Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Proliferation Involved In Immune Response Lipopolysaccharide Immune Receptor Activity Lymphocyte Activation Nuclear Body Interleukin-12-mediated Signaling Pathway SMN Complex Gemini Of Cajal Bodies Leukocyte Activation T-helper 1 Cell Differentiation SMN-Sm Protein Complex Small Nuclear Ribonucleoprotein Complex Response To Interleukin-6 Cell Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway B Cell Proliferation T Cell Differentiation Involved In Immune Response T-helper Cell Differentiation Ribonucleoprotein Complex Binding Spliceosomal SnRNP Assembly Nucleolus CD4-positive, Alpha-beta T Cell Differentiation
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