H2AZ2

Description		H2A.Z variant histone 2
Image
GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity Molecular Adaptor Activity
	Biological Process	Chromatin Organization Heterochromatin Formation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Novel Interacting Genes		4 novel interacting genes: APP DTX3L FBXO7 GSK3A
Interacting Genes		4 interacting genes: APP DTX3L FBXO7 GSK3A
Entrez ID		94239
HPRD ID		13623
Ensembl ID		ENSG00000105968
Uniprot IDs		Q71UI9
PDB IDs		3WAA 6M4D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Growth Cone Lamellipodium Chromatin Remodeling Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of UDP-glucose Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Protein K48-linked Ubiquitination Lewy Body Corona Lewy Neurite Histone H4K91 Ubiquitin Ligase Activity Proteolysis Involved In Protein Catabolic Process Notch Signaling Pathway Protein-containing Complex Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Acetylcholine Receptor Activator Activity Chromatin Organization Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Localization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development
Tagcloud ?