HAND1

Description		heart and neural crest derivatives expressed 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis In Utero Embryonic Development Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Regulation Of Transcription By RNA Polymerase II Heart Development Cell Differentiation Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Determination Of Heart Left/right Asymmetry
Pathways		Cardiogenesis
Drugs
Diseases
GWAS		Chin dimples ( 27182965) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Global electrical heterogeneity phenotypes ( 29622589) Monobrow ( 27182965) QRS complex (Cornell) ( 27659466) QRS duration ( 25035420 27577874 30679814 31251759)
Novel Interacting Genes		16 novel interacting genes: ACHE DNMT3L FHL2 G3BP1 HAND2 HEY2 HEYL KRTAP10-6 MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3
Interacting Genes		16 interacting genes: ACHE DNMT3L FHL2 G3BP1 HAND2 HEY2 HEYL KRTAP10-6 MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3
Entrez ID		9421
HPRD ID		03871
Ensembl ID		ENSG00000113196
Uniprot IDs		O96004
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity BHLH Transcription Factor Binding Positive Regulation Of Biosynthetic Process E-box Binding Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Cell Differentiation Nucleus Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Mesenchymal Cell Development Regulation Of Metabolic Process Chromatin Regulation Of Neuron Differentiation Outflow Tract Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Developmental Process Regulation Of RNA Metabolic Process Striated Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Macromolecule Biosynthetic Process Coronary Vasculature Morphogenesis Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Muscle System Process Positive Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Heart Trabecula Formation Positive Regulation Of Neuron Differentiation Cell Differentiation Cell Development Positive Regulation Of RNA Metabolic Process Muscle Cell Development
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