ORMDL3

Description		ORMDL sphingolipid biosynthesis regulator 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Serine Palmitoyltransferase Complex Secretory Granule Membrane Specific Granule Membrane
	Molecular Function	Protein Binding
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Regulation Of Ceramide Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 17611496 29273806 31959851 28461288 22561531 21150878 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 21102463 28067908 18587394) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 25751624 30659077 21829393 19430480) Ulcerative colitis ( 28067908 21297633 20228799) White blood cell count ( 27863252 21738480)
Novel Interacting Genes		35 novel interacting genes: APP AQP6 ARL13B C10orf67 CCR7 CDC27 CERS3 COQ8A CRHR1 EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 KRT13 LEPROTL1 LMNA LNX1 MED1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35H1 SLC7A1 SYT2 TMEM237
Interacting Genes		35 interacting genes: APP AQP6 ARL13B C10orf67 CCR7 CDC27 CERS3 COQ8A CRHR1 EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 KRT13 LEPROTL1 LMNA LNX1 MED1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35H1 SLC7A1 SYT2 TMEM237
Entrez ID		94103
HPRD ID		17803
Ensembl ID		ENSG00000172057
Uniprot IDs		Q8N138
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2
Enriched GO Terms of Interacting Partners?		Membrane
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