COX5A

Description		cytochrome c oxidase subunit 5A
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Metal Ion Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration Proton Transmembrane Transport
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly
Drugs		Cholic Acid N-Formylmethionine
Diseases
GWAS		Caffeine consumption ( 21490707) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Novel Interacting Genes		10 novel interacting genes: COPS6 CYP1A1 EPM2A EXOSC8 HTRA1 KRT31 KRT40 MESD MT-CO1 SPDEF
Interacting Genes		10 interacting genes: COPS6 CYP1A1 EPM2A EXOSC8 HTRA1 KRT31 KRT40 MESD MT-CO1 SPDEF
Entrez ID		9377
HPRD ID		04799
Ensembl ID		ENSG00000178741
Uniprot IDs		P20674
PDB IDs		5Z62
Enriched GO Terms of Interacting Partners?		Epithelial Cell Differentiation Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Dibenzo-p-dioxin Metabolic Process Arachidonate Monooxygenase Activity Response To Copper Ion Coumarin Metabolic Process Insecticide Metabolic Process Response To Diphenyl Ether Developmental Process Ethylene Metabolic Process Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Phosphatase Activity Carbohydrate Phosphatase Activity Starch Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Lung Goblet Cell Differentiation Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Heme Binding Response To Iron(III) Ion Demethylase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity Habituation Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Glandular Epithelial Cell Development Long-chain Fatty Acid Omega-hydroxylase Activity Response To Phenylpropanoid Retinoic Acid Biosynthetic Process Lipid Hydroxylation Estrogen 16-alpha-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Intermediate Filament Chorionic Trophoblast Cell Differentiation Nonassociative Learning Negative Regulation Of Dephosphorylation Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Exoribonuclease Complex
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