HAUS8

Description		HAUS augmin like complex subunit 8
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Nuclear Microtubule HAUS Complex Mitotic Spindle Microtubule
	Molecular Function	Protein Binding Microtubule Binding
	Biological Process	Centrosome Cycle Regulation Of Microtubule Nucleation Spindle Assembly Cell Division
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
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Diseases
GWAS		Mean corpuscular hemoglobin concentration ( 32888494) Mosquito bite size ( 28199695) Selective IgA deficiency ( 27723758) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		14 novel interacting genes: APP C1orf216 CCHCR1 DEUP1 HAUS6 HSPB1 NME7 NRDE2 NTAQ1 NUP54 OGT TXN2 USHBP1 ZG16B
Interacting Genes		14 interacting genes: APP C1orf216 CCHCR1 DEUP1 HAUS6 HSPB1 NME7 NRDE2 NTAQ1 NUP54 OGT TXN2 USHBP1 ZG16B
Entrez ID		93323
HPRD ID		11318
Ensembl ID		ENSG00000131351
Uniprot IDs		Q9BT25
PDB IDs		7SQK
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Microtubule-based Transport Transport Along Microtubule Amylin Binding Positive Regulation Of Toll Signaling Pathway Microtubule-based Process Negative Regulation Of Protein Kinase C Signaling Spindle Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Microtubule Nucleation Protein-N-terminal Glutamine Amidohydrolase Activity
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