S1PR2

Description		sphingosine-1-phosphate receptor 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Integrin Binding Protein Binding Lipid Binding G Protein-coupled Peptide Receptor Activity Sphingosine-1-phosphate Receptor Activity
	Biological Process	Sphingosine-1-phosphate Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Filopodium Assembly Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Postsynapse Assembly Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Novel Interacting Genes		4 novel interacting genes: GNA13 GNAI1 GNAQ KEAP1
Interacting Genes		4 interacting genes: GNA13 GNAI1 GNAQ KEAP1
Entrez ID		9294
HPRD ID		05488
Ensembl ID		ENSG00000267534
Uniprot IDs		O95136
PDB IDs		7T6B
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E GTPase Activity GTP Binding Neuropeptide Signaling Pathway G Protein-coupled Receptor Signaling Pathway Centriolar Satellite D5 Dopamine Receptor Binding D2 Dopamine Receptor Binding Midbody Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Response To Ketone Positive Regulation Of Protein Localization To Cell Cortex Response To Alcohol Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Rho-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Protein Localization To Cell Cortex Negative Regulation Of Response To Oxidative Stress Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Lysosomal Membrane Phototransduction, Visible Light Nucleotide Binding Cellular Response To Forskolin Regulation Of Relaxation Of Muscle G Protein-coupled Glutamate Receptor Signaling Pathway Response To Forskolin Cellular Response To Acidic PH Inclusion Body G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cholesterol Biosynthetic Process Detection Of Visible Light Cellular Response To Interleukin-4 Extracellular Exosome Response To Acidic PH
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