CRLF1

Description		cytokine receptor like factor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol External Side Of Plasma Membrane Receptor Complex CRLF-CLCF1 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Ureteric Bud Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		IL-6-type cytokine receptor ligand interactions Interleukin-27 signaling
Drugs
Diseases		Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Blood protein levels ( 30072576) Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808)
Novel Interacting Genes		2 novel interacting genes: CLCF1 CNTFR
Interacting Genes		2 interacting genes: CLCF1 CNTFR
Entrez ID		9244
HPRD ID		09177
Ensembl ID		ENSG00000006016
Uniprot IDs		O75462
PDB IDs		8D7H
Enriched GO Terms of Interacting Partners?		CNTFR-CLCF1 Complex Interleukin-11 Receptor Activity Signaling Receptor Binding Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Cytokine-mediated Signaling Pathway Interleukin-11 Binding Positive Regulation Of Isotype Switching To IgE Isotypes CRLF-CLCF1 Complex Ciliary Neurotrophic Factor Receptor Binding Interleukin-11-mediated Signaling Pathway Brainstem Development Suckling Behavior Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Astrocyte Differentiation Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Extrinsic Component Of Membrane Skeletal Muscle Organ Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Sex Differentiation Positive Regulation Of Isotype Switching Regulation Of Astrocyte Differentiation Regulation Of Isotype Switching Positive Regulation Of Glial Cell Differentiation Cytokine Binding Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of B Cell Proliferation Cytokine Receptor Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of B Cell Proliferation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Gliogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Glial Cell Differentiation Regulation Of Cell Population Proliferation Positive Regulation Of DNA Recombination Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Feeding Behavior Positive Regulation Of B Cell Activation Regulation Of Gliogenesis Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway
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