MSC

Description		musculin
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Branchiomeric Skeletal Muscle Development Roof Of Mouth Development Diaphragm Development Cellular Response To Leukemia Inhibitory Factor
Pathways
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 30395268) Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 33547301) Depression in smokers ( 30219690) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Homeostasis model assessment of insulin resistance x saturated fatty acids interaction ( 30327367) Late-onset myasthenia gravis ( 26562150) Optic disc size ( 31809533) QT interval ( 29213071) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Novel Interacting Genes		8 novel interacting genes: EWSR1 GORASP2 ID2 LNX1 PBX2 TCF12 TCF3 TCF4
Interacting Genes		8 interacting genes: EWSR1 GORASP2 ID2 LNX1 PBX2 TCF12 TCF3 TCF4
Entrez ID		9242
HPRD ID		04694
Ensembl ID		ENSG00000178860
Uniprot IDs		O60682
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Regulation Of Neuron Differentiation Transcription Regulator Complex E-box Binding Positive Regulation Of Neuron Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nervous System Development BHLH Transcription Factor Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Euchromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Differentiation Protein Heterodimerization Activity Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process System Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of RNA Metabolic Process B Cell Differentiation Endodermal Digestive Tract Morphogenesis Developmental Process Thigmotaxis Beta-catenin-TCF7L2 Complex Vitamin D Response Element Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Bundle Of His Development Regulation Of B Cell Activation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Cell Differentiation Positive Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II TFIIB-class Transcription Factor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process B Cell Lineage Commitment Negative Regulation Of B Cell Differentiation Positive Regulation Of Biosynthetic Process Regulation Of DNA-binding Transcription Factor Activity Enucleate Erythrocyte Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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