BUB3

Description		BUB3 mitotic checkpoint protein
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex
	Molecular Function	Protein Binding Ubiquitin Binding
	Biological Process	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Chromosome Segregation
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Body mass index ( 28892062) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Left-handedness ( 32989287) Lung volume ( 34128465) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)
Novel Interacting Genes		20 novel interacting genes: ANXA1 BUB1 BUB1B CEBPA CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 REXO4 RPL37A SUGT1 THRA TOP1 UBA1 WBP4
Interacting Genes		20 interacting genes: ANXA1 BUB1 BUB1B CEBPA CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 REXO4 RPL37A SUGT1 THRA TOP1 UBA1 WBP4
Entrez ID		9184
HPRD ID		04761
Ensembl ID		ENSG00000154473
Uniprot IDs		A0A140VJF3 O43684
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway NAD+-protein-serine ADP-ribosyltransferase Activity Nucleus NuRD Complex DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Sin3-type Complex Protein Lysine Delactylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Cell Fate Specification Fungiform Papilla Formation Chromatin Remodeling Meiotic Sister Chromatid Cohesion, Centromeric NF-kappaB Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Chromatin Binding Hair Follicle Placode Formation Histone Deacetylase Binding Histone Deacetylase Complex Circadian Rhythm Macromolecule Metabolic Process Regulation Of Cell Fate Commitment Regulation Of Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Response To Temperature Stimulus Chromatin Organization Chromosome Organization Positive Regulation Of Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Protein Auto-ADP-ribosylation Positive Regulation Of Developmental Process Meiotic Sister Chromatid Cohesion Cytosol NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Stem Cell Population Maintenance Response To Steroid Hormone NAD+-protein-aspartate ADP-ribosyltransferase Activity Protein Lysine Deacetylase Activity Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Stem Cell Differentiation Eyelid Development In Camera-type Eye Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
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