NLRP12

Description		NLR family pyrin domain containing 12
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Protein-macromolecule Adaptor Activity Cysteine-type Endopeptidase Activator Activity
	Biological Process	Negative Regulation Of Cytokine Production Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Dendritic Cell Migration Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases		Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Fasting glucose ( 33381925) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Testicular germ cell tumor ( 28604728)
Novel Interacting Genes		3 novel interacting genes: FAF1 IRAK1 PYCARD
Interacting Genes		3 interacting genes: FAF1 IRAK1 PYCARD
Entrez ID		91662
HPRD ID		14803
Ensembl ID		ENSG00000142405
Uniprot IDs		P59046
PDB IDs		2L6A 4XHS 5H7N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Heat Shock Protein Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Interleukin-1 Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Myosin I Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Innate Immune Response Ooplasm Fas Signaling Pathway AIM2 Inflammasome Complex Myeloid Dendritic Cell Activation Involved In Immune Response Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Stress Toll Signaling Pathway Positive Regulation Of Cell-cell Adhesion Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Positive Regulation Of Cell Communication Positive Regulation Of Innate Immune Response Positive Regulation Of Signaling Toll-like Receptor 2 Signaling Pathway CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Interleukin-6 Receptor Binding IkappaB Kinase Complex Macropinocytosis Immune Response-activating Signaling Pathway Interleukin-33-mediated Signaling Pathway Osmosensory Signaling Pathway
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