NEURL1

Description		neuralized E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Dendritic Spine Perikaryon Synapse Perinuclear Region Of Cytoplasm Apical Dendrite Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Translation Regulator Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Translation Protein Monoubiquitination Notch Signaling Pathway Sperm Axoneme Assembly Nervous System Development Skeletal Muscle Tissue Development Lactation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Communication Protein Ubiquitination Regulation Of Signaling Flagellated Sperm Motility Positive Regulation Of Apoptotic Process Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Filopodium Assembly Positive Regulation Of Dendritic Spine Development Cellular Response To Amino Acid Stimulus Positive Regulation Of Synapse Maturation Regulation Of Postsynapse Assembly
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 30061737) Early onset atrial fibrillation ( 28460022) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29617998) Prevalent atrial fibrillation ( 28416818) Response to antidepressants (symptom improvement) ( 29160301)
Novel Interacting Genes		3 novel interacting genes: UBE2D1 UBE2H UBE2N
Interacting Genes		3 interacting genes: UBE2D1 UBE2H UBE2N
Entrez ID		9148
HPRD ID		04815
Ensembl ID		ENSG00000107954
Uniprot IDs		B4DS86 O76050
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Regulation Of Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Post-translational Protein Modification Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Regulation Of TOR Signaling Proteolysis Regulation Of Protein Ubiquitination ATP Binding UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Cellular Response To Nutrient Levels Ubiquitin Conjugating Enzyme Complex Protein Modification Process Nucleotide Binding Transferase Activity Positive Regulation Of Protein Modification Process Catabolic Process Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Response To Nutrient Levels Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Modification Process DNA Double-strand Break Processing Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Postreplication Repair Positive Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination Protein Monoubiquitination Negative Regulation Of BMP Signaling Pathway
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