MTMR4

Description		myotubularin related protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endosome Cytosol Endosome Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Early Phagosome Membrane Recycling Endosome Membrane
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Molecular Adaptor Activity R-SMAD Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Phosphatidylinositol Dephosphorylation Midbody Abscission Phagosome Maturation Negative Regulation Of Endocytic Recycling
Pathways		Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS		Cognitive function ( 25644384) Refractive error ( 32231278) Vitamin D levels ( 25208829)
Novel Interacting Genes		2 novel interacting genes: HIPK3 NEDD4
Interacting Genes		2 interacting genes: HIPK3 NEDD4
Entrez ID		9110
HPRD ID		11945
Ensembl ID		ENSG00000108389
Uniprot IDs		A0A804HJV7 Q9NYA4
PDB IDs
Enriched GO Terms of Interacting Partners?		Sodium Channel Inhibitor Activity DNA-templated Transcription Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of JUN Kinase Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Potassium Channel Inhibitor Activity Endocardial Cushion Development Negative Regulation Of Sodium Ion Transport Proline-rich Region Binding Receptor Catabolic Process RNA Polymerase Binding Negative Regulation Of Potassium Ion Transmembrane Transport Nucleobase-containing Compound Biosynthetic Process Peptidyl-threonine Phosphorylation Negative Regulation Of MAP Kinase Activity Apicolateral Plasma Membrane Viral Budding Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Protein Targeting To Lysosome Negative Regulation Of Potassium Ion Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of JNK Cascade Neuromuscular Junction Development Peptidyl-serine Phosphorylation Receptor Metabolic Process Protein Localization To Lysosome Protein Modification Process Negative Regulation Of Signal Transduction Receptor Internalization Regulation Of Dendrite Morphogenesis Establishment Of Protein Localization To Vacuole Negative Regulation Of Cation Transmembrane Transport Mesenchyme Development RNA Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cell Communication Outflow Tract Morphogenesis Steroid Hormone Receptor Signaling Pathway
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