CDKL2

Description		cyclin dependent kinase like 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Sex Differentiation Regulation Of Cell Cycle
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)
Novel Interacting Genes		3 novel interacting genes: APP CBL G3BP2
Interacting Genes		3 interacting genes: APP CBL G3BP2
Entrez ID		8999
HPRD ID		16021
Ensembl ID		ENSG00000138769
Uniprot IDs		A0A140VJG1 B4DH08 J3KNE8 Q92772
PDB IDs		4AAA 4BBM 8S6I
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Ephrin Receptor Binding Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity Positive Regulation Of Cellular Component Organization Membrane Raft Amyloid-beta Complex PTB Domain Binding Protein Homooligomerization Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Growth Cone Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Complex Oligomerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Rap Protein Signal Transduction Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Main Axon Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Response To Growth Factor Regulation Of Synapse Structure Or Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Toll Signaling Pathway Regulation Of Endocytosis Ubiquitin-dependent Endocytosis
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